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dieldrin

Identification (Source:EPA,EU)

ID	1476
Name	dieldrin
CAS	60-57-1
IUPAC
Inchi	InChI=1S/C12H8Cl6O/c13-8-9(14)11(16)5-3-1-2(6-7(3)19-6)4(5)10(8,15)12(11,17)18/h2-7H,1H2/t2-,3+,4+,5-,6-,7+,10+,11-
CIPAC	16
EPA Code	045001
Formula	C12H8Cl6O
SMILES	Cl\C1=C(/Cl)C2(Cl)C3C4CC(C3C1(Cl)C2(Cl)Cl)C5OC45
Status	Not Approved

Classification

Mode of Action	Central nervous system stimulant. GABA-gated chloride channel antagonist.
Pesticide Type	Insecticide, Metabolite
Chemical Group	Chlorinated hydrocarbon
Classification	cyclodiene insecticides

Properties (Source:PubChem)

Molecular Weight	380.91
Physical State	White to light brown crystals
AlogP	3.406
H-Bond Donor	0
H-Bond Acceptor	1
Surface Area	273.36
Polar Surface Area	12.53

Structure

Ecotoxicology (Source:PPDB,IPM)

Species	Method	Study Time	Dose Type	Value
Algae	Acute	72 hour	EC50, growth	0.1 mg l-1
Aquatic invertebrates	Acute	48 hour	EC50	0.25 mg l-1
Birds	Acute		LD50	153 mg kg-1
Fish	Acute	96 hour	LC50	0.0012 mg l-1
Honeybees	Acute	48 hour	LD50	0.32 μg bee-1
Mammals	Acute oral		LD50	46 mg kg-1
Mammals	Short term dietary		NOEL	0.5 ppm diet
	Bio-concentration factor		BCF	35000
	Bio-concentration factor		CT50	Not available days

Related targets

Target Name	RScore (About this table)
caspase 3	872(6,18,19,27)	Details
GABA receptor (protein family or complex)	1054(6,17,40,129)	Details
chloride channel (protein family or complex)	617(5,11,12,32)	Details
bcl 2	415(5,5,6,10)	Details
ATPase	445(4,7,10,20)	Details
CF 1 (protein family or complex)	434(4,5,18,19)	Details
NMDA receptor (protein family or complex)	305(3,5,5,5)	Details
cytochrome P450 (protein family or complex)	332(3,4,8,42)	Details
PLA2	248(3,3,3,8)	Details
protein kinase C delta	243(3,3,3,3)	Details
estrogen receptors	359(2,6,8,69)	Details
alpha synuclein	266(2,4,10,16)	Details
Connexin 43	239(2,4,5,14)	Details
heme oxygenase 1	218(2,3,7,8)	Details
IL 6	195(2,3,3,5)	Details
acid phosphatase	193(2,3,3,3)	Details
brains	260(1,5,13,20)	Details
cytochrome c	151(1,3,4,6)	Details
albumin	150(1,3,3,10)	Details
metabotropic glutamate receptor 5	144(1,3,3,4)	Details
SRBC	131(1,2,5,6)	Details
Acetylcholinesterase	125(1,2,3,10)	Details
neurotrophin	115(1,2,2,5)	Details
ERK1	114(1,2,2,4)	Details
protein kinase C (protein family or complex)	97(1,1,2,12)	Details
TGFbeta	96(1,1,2,11)	Details
adenylate cyclase	96(1,1,1,16)	Details
ATPases	88(1,1,1,8)	Details
aryl hydrocarbon receptor	88(1,1,1,8)	Details
glycine receptor (protein family or complex)	87(1,1,1,7)	Details
pregnane X receptor	85(1,1,1,5)	Details
jen	83(1,1,1,3)	Details
complex is	82(1,1,1,2)	Details
GABA at	82(1,1,1,2)	Details
androgen receptor	82(1,1,1,2)	Details
PARP	81(1,1,1,1)	Details
beta glucosidase	81(1,1,1,1)	Details
caspase 9	81(1,1,1,1)	Details
AP 1 (protein family or complex)	81(1,1,1,1)	Details
Jun N terminal kinase (protein family or complex)	81(1,1,1,1)	Details
ribonuclease	81(1,1,1,1)	Details
interleukin 8	81(1,1,1,1)	Details
calmodulin	136(0,4,5,11)	Details
caspase (protein family or complex)	97(0,3,3,7)	Details
ubiquitin	75(0,2,4,5)	Details
CYP3A	71(0,2,2,11)	Details
FRAP	65(0,2,2,5)	Details
succinate dehydrogenase (protein family or complex)	64(0,2,2,4)	Details
CACA	63(0,2,2,3)	Details
mitogen activated protein kinase (protein family or complex)	62(0,2,2,2)	Details
PEPCK	57(0,1,5,7)	Details
superoxide dismutase	46(0,1,2,11)	Details
dopamine transporter	42(0,1,2,7)	Details
SPMD	40(0,1,2,5)	Details
ER beta	40(0,1,1,10)	Details
vascular endothelial growth factor	39(0,1,1,9)	Details
neurotrophic factors	38(0,1,2,3)	Details
glutathione S transferase	38(0,1,1,8)	Details
transferase	38(0,1,1,8)	Details
CF1	37(0,1,1,7)	Details
CYP2B	36(0,1,1,6)	Details
NF kappa B	36(0,1,1,6)	Details
tryptophan hydroxylase	34(0,1,1,4)	Details
cis 4	33(0,1,1,3)	Details
cytosolic epoxide hydrolase	33(0,1,1,3)	Details
p38	32(0,1,1,2)	Details
alanine aminotransferase	32(0,1,1,2)	Details
rd1	31(0,1,1,1)	Details
TLR3	31(0,1,1,1)	Details
transcription factor AP 1	31(0,1,1,1)	Details
NADH dehydrogenase	31(0,1,1,1)	Details
MC7	31(0,1,1,1)	Details
E12	31(0,1,1,1)	Details
ET A	31(0,1,1,1)	Details
Beach	31(0,1,1,1)	Details
caspase 12	31(0,1,1,1)	Details
U82	31(0,1,1,1)	Details
phosphoglucomutase 2	31(0,1,1,1)	Details
muscles	29(0,0,3,14)	Details

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