permethrin
Identification (Source:EPA,EU)
| ID |
276 |
| Name |
permethrin |
| CAS |
52645-53-1 |
| IUPAC |
|
| Inchi |
InChI=1S/C21H20Cl2O3/c1-21(2)17(12-18(22)23)19(21)20(24)25-13-14-7-6-10-16(11-14)26-15-8-4-3-5-9-15/h3-12,17,19H,13H2,1-2H3 |
| CIPAC |
331 |
| EPA Code |
109701 |
| Formula |
C21H20Cl2O3 |
| SMILES |
c3ccccc3Oc(c2)cccc2COC(=O)C1C(C1(C)C)C=C(Cl)Cl |
| Status |
Approved |
Classification
Properties (Source:PubChem)
| Molecular Weight |
391.3 |
| Physical State |
Colourless crystalline solid to brown viscous liquid depending upon purity |
| AlogP |
5.438 |
| H-Bond Donor |
0 |
| H-Bond Acceptor |
3 |
| Surface Area |
363.87 |
| Polar Surface Area |
35.53 |
Structure
Ecotoxicology (Source:PPDB,IPM)
| Species |
Method |
Study Time |
Dose Type |
Value |
| Algae |
Chronic |
96 hour |
NOEC, growth |
0.0009 mg l-1 |
| Algae |
Acute |
72 hour |
EC50, growth |
0.0125 mg l-1 |
| Aquatic crustaceans |
Acute |
96 hour |
LC50 |
0.00002 mg l-1 |
| Aquatic invertebrates |
Acute |
48 hour |
EC50 |
0.0006 mg l-1 |
| Birds |
Acute |
|
LD50 |
> 9800 mg kg-1 |
| Earthworms |
Acute |
14 day |
LD50 |
1440 mg kg-1 |
| Fish |
Chronic |
21 day |
NOEC |
0.00012 mg l-1 |
| Fish |
Acute |
96 hour |
LC50 |
0.0125 mg l-1 |
| Honeybees |
Acute |
48 hour |
LD50 |
0.029 μg bee-1 |
| Mammals |
Acute oral |
|
LD50 |
> 430 mg kg-1 |
| Mammals |
Short term dietary |
|
NOEL |
100 ppm diet |
| Sediment dwelling organisms |
Acute |
96 hour |
LC50 |
0.0029 mg l-1 |
|
Bio-concentration factor |
|
CT50 |
Not available days |
|
Bio-concentration factor |
|
BCF |
300 |
Related targets
| Target Name |
RScore (About this table) |
|
|
ATPase
|
638(6,10,12,28) |
Details |
|
cytochrome P450 (protein family or complex)
|
427(3,6,15,52) |
Details |
|
Acetylcholinesterase
|
422(3,6,15,47) |
Details |
|
cytochrome P450 monooxygenases
|
323(3,5,7,13) |
Details |
|
Cl 2
|
253(3,3,3,13) |
Details |
|
androgen receptor
|
251(3,3,3,11) |
Details |
|
M2 muscarinic acetylcholine receptor
|
194(2,3,3,4) |
Details |
|
sodium channel (protein family or complex)
|
440(1,5,33,100) |
Details |
|
estrogen receptor alpha
|
180(1,4,4,10) |
Details |
|
c fos
|
169(1,3,6,14) |
Details |
|
calmodulin
|
166(1,3,5,16) |
Details |
|
CYP3A4
|
162(1,3,4,17) |
Details |
|
cholinesterase
|
155(1,3,3,15) |
Details |
|
hCE 2
|
118(1,2,2,8) |
Details |
|
P450scc
|
112(1,2,2,2) |
Details |
|
steroidogenic acute regulatory protein
|
112(1,2,2,2) |
Details |
|
benzodiazepine receptor (protein family or complex)
|
112(1,2,2,2) |
Details |
|
adenylate cyclase
|
91(1,1,2,6) |
Details |
|
phosphodiesterase
|
91(1,1,2,6) |
Details |
|
acetylcholine receptor (protein family or complex)
|
88(1,1,2,3) |
Details |
|
CYP2B6
|
87(1,1,1,7) |
Details |
|
ornithine decarboxylase
|
87(1,1,2,2) |
Details |
|
monoamine oxidase A
|
85(1,1,1,5) |
Details |
|
complex I
|
85(1,1,1,5) |
Details |
|
CYP1A1
|
84(1,1,1,4) |
Details |
|
calcineurin (protein family or complex)
|
84(1,1,1,4) |
Details |
|
alkaline phosphatase
|
84(1,1,1,4) |
Details |
|
PC3
|
84(1,1,1,4) |
Details |
|
lactate dehydrogenase (protein family or complex)
|
83(1,1,1,3) |
Details |
|
MEST
|
83(1,1,1,3) |
Details |
|
MAPK (protein family or complex)
|
82(1,1,1,2) |
Details |
|
CYP2D
|
81(1,1,1,1) |
Details |
|
myeloperoxidase
|
81(1,1,1,1) |
Details |
|
succinate dehydrogenase (protein family or complex)
|
81(1,1,1,1) |
Details |
|
CYP3A5
|
81(1,1,1,1) |
Details |
|
CYP2A6
|
81(1,1,1,1) |
Details |
|
cis 1
|
81(1,1,1,1) |
Details |
|
glutathione S transferase
|
139(0,3,6,34) |
Details |
|
brain derived neurotrophic factor
|
109(0,3,5,9) |
Details |
|
HCE1
|
75(0,2,3,10) |
Details |
|
cytochrome c
|
65(0,1,5,15) |
Details |
|
dopamine transporter
|
50(0,1,3,10) |
Details |
|
IL 8
|
42(0,1,2,7) |
Details |
|
cis 3
|
37(0,1,1,7) |
Details |
|
ErbB 2
|
34(0,1,1,4) |
Details |
|
CA1
|
34(0,1,1,4) |
Details |
|
Camk1g
|
33(0,1,1,3) |
Details |
|
GABAT
|
33(0,1,1,3) |
Details |
|
epidermal growth factor
|
33(0,1,1,3) |
Details |
|
microtubule associated protein 2
|
32(0,1,1,2) |
Details |
|
net 1
|
32(0,1,1,2) |
Details |
|
choline acetylase
|
32(0,1,1,2) |
Details |
|
AP 1 (protein family or complex)
|
31(0,1,1,1) |
Details |
|
PC 3
|
31(0,1,1,1) |
Details |
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