NR2B

General Information (Source: NCBI Gene,UniProt)

Text mining Term NR2B
UniProt ID CKR_CONRA
Name Con-R
Conantokin-R
Gene Names
Taxonomy Conus radiatus

General annotation

Function Conantokins inhibit N-methyl-D-aspartate (NMDA) receptors. This toxin is potent in the following order of preference: NR2B approximately NR2A/GRIN2A > NR2C/GRIN2C >> NR2D/GRIN2D. Induces sleep-like symptoms in young mice. Is a highly potent anticonvulsant compound.
Subcellular location Secreted.

Gene Ontology

GO:0008200 ion channel inhibitor activity MF
GO:0035792 other organism postsynaptic membrane CC
GO:0046872 metal ion binding MF

Sequence

>gi|62906867|sp|P58806.2|CKR_CONRA RecName: Full=Conantokin-R; Short=Con-R; Flags: Precursor
MQLYTYLYLLVSLVTFYLILGTGTLGHGGALTERRSTDATALKPEPVLLQKSSARSTDDNGNDRLTQMKR
ILKKRGNKARGEEEVAKMAAELARENIAKGCKVNCYP

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Database Cross Reference

Ensembl Gene
UniGene
PDB
RefSeq
Pfam PF10550