phospholipase C beta 2

General Information (Source: NCBI Gene,UniProt)

Text mining Term phospholipase C beta 2
UniProt ID PLCB2_RAT
Name Phosphoinositide phospholipase C-beta-2
Phospholipase C-beta-2
PLC-beta-2
1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-2
Gene Names Plcb2
Taxonomy Rattus norvegicus

General annotation

Function The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. This protein may be involved in the transduction of bitter taste stimuli.
Subcellular location

Gene Ontology

GO:0005543 phospholipid binding MF
GO:0009395 phospholipid catabolic process BP
GO:0004871 signal transducer activity MF
GO:0005829 cytosol CC
GO:0031680 G-protein beta/gamma-subunit complex CC
GO:0005509 calcium ion binding MF
GO:0005794 Golgi apparatus CC
GO:0031683 G-protein beta/gamma-subunit complex binding MF
GO:0035556 intracellular signal transduction BP
GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste BP
GO:0005886 plasma membrane CC
GO:0004435 phosphatidylinositol phospholipase C activity MF

Sequence

>gi|16758232|ref|NP_445930.1| 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-2 [Rattus norvegicus]
MSLLNPVLLPPKVKAYLSQGERFIKWDDETSIASPVILRVDPKGYYLYWTHQSKEMEFLDVTSIRDTRFG
KFAKIPKSQKLREVFNMDFPDNHFLLKTFTVVSGPDMVGLTFHNFVSYKENVGKDWAEDVLALAKHPMTA
NASRSTFLDKILVKLKMQLSPEGKIPVKNFFQMFPADRKRVEAALSACHLAKGKNDAINPEDFPESVYKS
FLMSLCPRPEIDEIFTSYHAKAKPYMTKEHLTKFINQKQRDPRLNSLLFPPARPEQVQALIDKYEPSGIN
VQRGQLSPEGMVWFLCGPENSVLAHDTLRIHQDMTQPLNHYFINSSHNTYLTAGQFSGPSSAEMYRQVLL
SGCRCVELDCWKGKPPDEEPIITHGFTMTTDILFKEAVEAIAESAFKTSPYPVILSFENHVDSPRQQAKM
AEYCRTMFGETLLTEPLENFPLKPGMPLPSPEDLRGKILIKNKKNQFSGPASPNKKPDGVSEGGFPSSVP
VEEDTGWTAEDRTEVEEGEEEEEVEEEEEEESGNLDEEEIKKMQSDEGTAGLEVTAYEEMSSLVNYIQPT
KFISFEFSAQKNRSYLVSSFTELKAYELLSKASMQFVDYNKRQMSRVYPKGTRMDSSNYMPQMFWNAGCQ
MVALNFQTMDLPMQQNMALFEFNGQSGYLLKHEFMRRQDKQFNPFSVDRIDVVVATTLSITVISGQFLSE
RSVRTYVEVELFGLPGDPKRRYRTKLSPTANSINPVWKEEPFIFEKILVPELASLRIAVMEEGGKFIGHR
IIPINALHSGYHHLCLRSESNMPLTMPALFVFLEMKDYVPDTWADLTVALANPIKYFSAHDKKSVKLKEV
TGSLPEKLFSGIPVASQSNGAPVSAGNGSTAPGTKAKEEATKEVAEPQTTSLEELRELKGVVKLQRRHEK
ELRELERRGARRWEELLQRGAAQLAELQDPAASCKLRPGKGSRKKRIVPCEETIVVPREVLEGPDPRVQD
LKDRLEQELQQQGEEQYRSVLKRKEQHVTEQIAKMMELAREKQAAELKSFKETSETDTKEMKKKLEAKRL
ERIQAMTKVTTDKVAQERLKREINNSHIQEVVQAVKQMTETLERHQEKLEEKQTACLEQIQAMEKQFQEK
ALAEYEAKMKGLEAEVKESMRACFKACFPTEAEEKPERPCEASEESCPQEPLVNKTDTQESRL

Options for BLAST

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Database Cross Reference

Ensembl Gene
UniGene Rn.30033
PDB
RefSeq NP_445930.1
Pfam PF00387
PF08703
PF00388
PF09279
PF00168