p38

General Information (Source: NCBI Gene,UniProt)

Text mining Term p38
UniProt ID IF2B_WHEAT
Name Eukaryotic translation initiation factor 2 subunit beta
eIF-2-beta
P38
Gene Names
Taxonomy Triticum aestivum

General annotation

Function eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S preinitiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction catalyzed by eIF-2B (By similarity).
Subcellular location

Gene Ontology

GO:0046872 metal ion binding MF
GO:0003743 translation initiation factor activity MF

Sequence

>gi|3122234|sp|O24473.1|IF2B_WHEAT RecName: Full=Eukaryotic translation initiation factor 2 subunit beta; Short=eIF-2-beta; AltName: Full=P38
MADEEQMERKEEATEIAPFDPTKKKKKKKVVIQDPADEVDKLAEKTEGLSVTESGEASFVGLKKKKKKLV
ELDPSLVEAGDGEDTLDDQVGEDEQGEGIVLGGATQYPWEGTDRDYKYDELLGRVFNILRENNPDLAGDR
RRTVMRPPQVLREGTKKTVFVNFMDLCKTMHRQPEHVMMFLLAEMGTSGSLDGQQRLVIKGRFAPKNFEA
ILRRYINEYVICHGCKSPDTILSKENRLFFLRCEQCGSSRSVAPIKAGFVAQVGRRKAGT

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Database Cross Reference

Ensembl Gene
UniGene Ta.55064
PDB
RefSeq
Pfam PF01873