5 HT1A

General Information (Source: NCBI Gene,UniProt)

Text mining Term 5 HT1A
UniProt ID 5HT2A_DROME
Name 5-hydroxytryptamine receptor 2A
Serotonin receptor 2A
5-HT receptor 2A
Gene Names
Taxonomy Drosophila melanogaster

General annotation

Function This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins which inhibit adenylate cyclase.
Subcellular location Cell membrane; Multi-pass membrane protein.

Gene Ontology

GO:0045187 regulation of circadian sleep/wake cycle, sleep BP
GO:0007198 inhibition of adenylate cyclase activity by serotonin receptor signaling pathway BP
GO:0007208 activation of phospholipase C activity by serotonin receptor signaling pathway BP
GO:0001586 Gi/o-coupled serotonin receptor activity MF
GO:0016021 integral to membrane CC
GO:0005886 plasma membrane CC

Sequence

>gi|45647561|gb|AAS74378.1| 5-HT1A [Drosophila melanogaster]
APSTSGNQIATVSHLVALAKQQGKSTAKSSAAVNGMAPSGRQEDDGQRPEHGEQEDREELVDQDEQVGPQ
PTTATSATTAAGTNESEDQCKANGVEVLEDPQLQQQLEQVQQLQKSVKSGGGGGASTSNATTITSISALS
PQTPTSQGVGIAAAAAGPMTAKTSTLTSCNQSHPLCGTANESPSTPEPRSRQPTTPQXQXXXXAHQQQQQ
QQQLSSIANPMQKVNKRKETLEAKRERKAAKTLAIITGAFVVCWLPFFVMALTMPLCAACQISDSVASLF
LWLGYFNSTLNPVIYTIFSPEFRQAFKRILFGGHRPVHYRSGKL

Options for BLAST

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Database Cross Reference

Ensembl Gene
UniGene Dm.4703
PDB
RefSeq NP_476802.1
NP_725849.1
Pfam PF00001