helicase

General Information (Source: NCBI Gene,UniProt)

Text mining Term helicase
UniProt ID IF4A_WHEAT
Name ATP-dependent RNA helicase eIF4A
eIF-4A
Eukaryotic initiation factor 4A
Gene Names
Taxonomy Triticum aestivum

General annotation

Function ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon.
Subcellular location

Gene Ontology

GO:0003743 translation initiation factor activity MF
GO:0005524 ATP binding MF
GO:0008026 ATP-dependent helicase activity MF

Sequence

>gi|1170509|sp|P41378.1|IF4A_WHEAT RecName: Full=Eukaryotic initiation factor 4A; Short=eIF-4A; AltName: Full=ATP-dependent RNA helicase eIF4A
MAGMAPEGSQFDAKNYDSKMQELLSQGETEEFFTSYDEVHESFDDMGLQENLLRGIYAYGFEKPSAIQQR
GIVPFCKGLDVIQQAQSGTGKTATFCSGILQQLDYGLVECQALVLAPTRELAQQIEKVMRALGDYLGVKV
HACVGGTSVREDQRILASGVHVVVGTPGRVFDIVRRQSLRPDNIKMFVLDEADEMLSRGFKDQIYDIFQL
LPGKIQVGVFSATMPPEALEITRKFMNKPVRILVKRDELTLEGIKQFYVNVEKEEWKLDTLCDLYETLAI
TQSVIFVNTRRKVDWLTDKMRGRDHTVSATHGDMDQNTRDIIMREFRSGSSRVLITTDLLARGIDVQQVS
LVINYDLPTQPENYQHRIGRSGRFGRKGVAINFVTREDERMLFDIQKFYNVVIEELPANVADLL

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Database Cross Reference

Ensembl Gene
UniGene
PDB
RefSeq
Pfam PF00270
PF00271