muscles

General Information (Source: NCBI Gene,UniProt)

Text mining Term muscles
UniProt ID POTX_PARCV
Name Pac-TX
PoTX
Poneratoxin
Gene Names
Taxonomy Paraponera clavata

General annotation

Function Blocks nicotinic synaptic transmission in insect CNS and affects voltage-dependent sodium channels. It is a strong, but very slowly acting agonist for smooth muscles and its blocks synaptic transmission in the insect CNS in a concentration- dependent manner and depolarizes giant interneurons. Also affects neuromuscular transmission in rat tissue.
Subcellular location Secreted.

Gene Ontology

GO:0019871 sodium channel inhibitor activity MF
GO:0035792 other organism postsynaptic membrane CC
GO:0072556 other organism presynaptic membrane CC

Sequence

>gi|1172020|sp|P41736.1|POTX_PARCV RecName: Full=Poneratoxin; Short=PoTX; AltName: Full=Pac-TX
FLPLLILGSLLMTPPVIQAIHDAQR

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Database Cross Reference

Ensembl Gene
UniGene
PDB 1G92
RefSeq
Pfam