choline acetyltransferase

General Information (Source: NCBI Gene,UniProt)

Text mining Term choline acetyltransferase
UniProt ID CLAT_DROME
Name Choline O-acetyltransferase
Choline acetylase
ChAT
Choline O-acetyltransferase 67 kDa chain
Choline O-acetyltransferase 13 kDa chain
Choline O-acetyltransferase 54 kDa chain
CHOACTase
Gene Names Cha
Taxonomy Drosophila melanogaster

General annotation

Function Catalyzes the reversible synthesis of acetylcholine (ACh) from acetyl CoA and choline at cholinergic synapses.
Subcellular location

Gene Ontology

GO:0007399 nervous system development BP
GO:0008292 acetylcholine biosynthetic process BP
GO:0007274 neuromuscular synaptic transmission BP
GO:0005634 nucleus CC
GO:0005829 cytosol CC
GO:0004102 choline O-acetyltransferase activity MF

Sequence

>gi|61679360|gb|AAS65177.2| choline acetyltransferase, isoform B [Drosophila melanogaster]
MASNEASTSAAGSGPESAALFSKLRSFSIGSGPNSPQRVVSNLRGFLTHRLSNITPSDTGWKDSILSIPK
KWLSTAESVDEFGFPDTLPKVPVPALDETMADYIRALEPITTPAQLERTKELIRQFSAPQGIGARLHQYL
LDKREAEDNWAYYYWLNEMYMDIRIPLPINSNPGMVFPPRRFKTVHDVAHFAARLLDGILSHREMLDSGE
LPLERAASREKNQPLCMAQYYRLLGSCRRPGVKQDSQFLPSRERLNDEDRHVVVICRNQMYCVVLQASDR
GKLSESEIASQILYVLSDAPCLPAKPVPVGLLTAEPRSTWARDREMLQEDERNQRNLELIETAQVVLCLD
EPLAGNFNARGFTGATPTVHRAGDRDETNMAHEMIHGGGSEYNSGNRWFDKTMQLIICTDGTWGLCYEHS
CSEGIAVVQLLEKIYKKIEEHPDEDNGLPQHHLPPPERLEWHVGPQLQLRFAQASKSVDKCIDDLDFYVY
RYQSYGKTFIKSCQVSPDVYIQLALQLAHYKLYGRLVATYESASTRRFLHGRVDCIRAASTEALEWAKAM
CQGEGANVPLESDREDEEESRKKDHLRELFRCAVARQTEVMVKNILGNGIDIPLLGLREASIEVTGEMHE
LFKDESYIISQCFLLSTSQVACSTDSFMGYGPVTPRGYGCSYNPHPEQIVFCVSAFYSCEDTSASRYAKS
LQDSLDIMRDLLQN

Options for BLAST

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Database Cross Reference

Ensembl Gene
UniGene Dm.1244
PDB
RefSeq NP_996239.2
NP_477004.5
Pfam PF00755