NADPH cytochrome P450 reductase

General Information (Source: NCBI Gene,UniProt)

Text mining Term NADPH cytochrome P450 reductase
UniProt ID NCPR_ASPOR
Name CPR
NADPH--cytochrome P450 reductase
P450R
Gene Names cprA
Taxonomy Aspergillus oryzae RIB40

General annotation

Function This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5. Involved in ergosterol biosynthesis (By similarity).
Subcellular location Endoplasmic reticulum membrane; Single-pass membrane protein (By similarity). Cell membrane; Single-pass membrane protein (By similarity). Microsome (By similarity).

Gene Ontology

GO:0016021 integral to membrane CC
GO:0005789 endoplasmic reticulum membrane CC
GO:0003958 NADPH-hemoprotein reductase activity MF
GO:0016126 sterol biosynthetic process BP
GO:0005792 microsome CC
GO:0010181 FMN binding MF
GO:0005886 plasma membrane CC
GO:0005506 iron ion binding MF

Sequence

>gi|169773183|ref|XP_001821060.1| NADPH--cytochrome P450 reductase [Aspergillus oryzae RIB40]
MAQLDTLDLVVLVALLVGSVAYFTKGTYWAVAKDPYASSGPAMNGAAKAGKTRDILEKMEETGKNCVIFY
GSQTGTAEDYASRLAKEGSQRFGLKTMVADLEDYDYENLDKFPEDKVAFFVLATYGEGEPTDNAVEFYQF
ITGEDVAFESGASAEEKPLSALKYVTFGLGNNTYEHYNAMVRNLDAALQKLGAQRIGSAGEGDDGAGTME
EDFLAWKEPMWTALSEAMGLQEREAVYEPVFNVTEDESKSAEDETVYLGEPTKGHLEGQPKGPFSAHNPF
IAPIVESRELFTVKDRNCLHMEISIAGSNLTYQTGDHIAVWPTNAGAEVDRFLQVFGLEEKRHSVINIKG
IDVTAKVPIPTPTTYDAAVRYYMEVCAPVSRQFVSSLAAFAPDEATKTEIQRLGSDKDYFHEKITNQCFN
IAQALQSITSKPFSAVPFSLLIEGLNKLQPRYYSISSSSLVQKDKISITAVVESVRLPGASHLVKGVTTN
YLLALKQKQNGEPSPDPHGLTYAITGPRNKYDGIHVPVHVRHSNFKLPSDPSRPIIMVGPGTGVAPFRGF
IQERAALAAKGEKVGTTVLFFGCRNRNEDFLYQDEFKAYEEQLGDSLKIITAFSRETSQKVYVQHRLREQ
AELVSDLLKQKATFYVCGDAANMAREVNLVLGQIIAQQRGLPAEKGEEMVKHMRSSGSYQEDVWS

Options for BLAST

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Database Cross Reference

Ensembl Gene
UniGene
PDB
RefSeq XP_001821060.1
Pfam PF00175
PF00667
PF00258