POLL

General Information (Source: NCBI Gene,UniProt)

Text mining Term POLL
UniProt ID MED11_DROME
Name dMED21
Mediator of RNA polymerase II transcription subunit 11
Mediator complex subunit 11
Gene Names MED11
Synonyms:Med21
Taxonomy Drosophila melanogaster

General annotation

Function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
Subcellular location Nucleus (Probable).

Gene Ontology

GO:0005515 protein binding MF
GO:0001104 RNA polymerase II transcription cofactor activity MF
GO:0048813 dendrite morphogenesis BP
GO:0007517 muscle organ development BP
GO:0016592 mediator complex CC

Sequence

>gi|21358009|ref|NP_649057.1| mediator complex subunit 11 [Drosophila melanogaster]
MNPLDKIHALDEIEKEIILCMQSAGQALQELGKEKSSQKNAETQSQQFLKSLSSVESKLSEQINYLTQVS
TGQPHEGSGYASAKVLQMAWHRIQHARSRVRELEETKAKHSHAARQQLKRQQEHAAAQQQQQQQQQQQQQ
QQQMQQAAQQQQQQTGGGNAGSGDHPMGGDSSMSTN

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Database Cross Reference

Ensembl Gene
UniGene Dm.14493
PDB
RefSeq NP_649057.1
Pfam PF10280