aspartate aminotransferase

General Information (Source: NCBI Gene,UniProt)

Text mining Term aspartate aminotransferase
UniProt ID DDC_MANSE
Name AADC
Aromatic-L-amino-acid decarboxylase
DDC
DOPA decarboxylase
Gene Names Ddc
Taxonomy Manduca sexta

General annotation

Function Catalyzes the decarboxylation of L-3,4- dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine.
Subcellular location

Gene Ontology

GO:0042423 catecholamine biosynthetic process BP
GO:0004058 aromatic-L-amino-acid decarboxylase activity MF
GO:0006520 cellular amino acid metabolic process BP
GO:0030170 pyridoxal phosphate binding MF

Sequence

>gi|1352212|sp|P48861.1|DDC_MANSE RecName: Full=Aromatic-L-amino-acid decarboxylase; Short=AADC; AltName: Full=DOPA decarboxylase; Short=DDC
MNPGDFKDFAKAMTDYITEYLENIRDRQVVPSVKPGYLRPLVPEQAPQQAEPWTAVMADIERVVMSGVTH
WQSPRFHAYFPTANSYPSIVADMLSGAIACIGFTWIASPACTELEVVMLDWLGQMLGLPDQFLARSGGEG
GGVIQGTASEATFVALLGAKSRMMHRVKEQHPEWTETDILGKLVGYCNQQAHSSVERAGLLGGVKLRSLK
PDSKRRLRGDTLREAIDEDIRNGLIPFYVVATLGTTSSCAFDALDEIGDVCNASDIWLHVDAAYAGSAFI
CPEYRHFMKGVEKADSFNFNPHKWMLVNFDCSAMWLKQPRWIVDAFNVDPLYLKHEQQGSAPDYRHWQIP
LGRRFRSLKLWFVLRLYGVENLQKYIRKQIGFAHLFERLLTSDERFELFEEVTMGLVCFRLKGSNEINEE
LLRRINGRGKIHLVPSKVDDVYFLRLAICSRFTEESDMHVSWEEIKDRLMMFLKSKGAVLIKIICSTTRR
TKNILTYIKQNIFRDVGL

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Database Cross Reference

Ensembl Gene
UniGene
PDB
RefSeq
Pfam PF00282