dihydrofolate reductase

General Information (Source: NCBI Gene,UniProt)

Text mining Term dihydrofolate reductase
UniProt ID DYR_CRYNJ
Name Dihydrofolate reductase
Gene Names DFR1
Synonyms:DHFR
Taxonomy Cryptococcus neoformans var. neoformans JEC21

General annotation

Function Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity).
Subcellular location

Gene Ontology

GO:0050661 NADP binding MF
GO:0009165 nucleotide biosynthetic process BP
GO:0006730 one-carbon metabolic process BP
GO:0004146 dihydrofolate reductase activity MF
GO:0006545 glycine biosynthetic process BP

Sequence

>gi|58259912|ref|XP_567366.1| dihydrofolate reductase [Cryptococcus neoformans var. neoformans JEC21]
MFPPGTTCKSNSTPSQHRCMRPLLNALRTMQTTAKSSTPSITAVVAATAENGIGLNGGLPWRLPGEMKYF
ARVTTGETPSSDPSEQNVVIMGRKTWESIPSRFRPLKNRRNVVISGKGVDLGTAENSTVYTDIPSALSAL
RSTTESGHSPRIFLIGGATLYTSSLLPSSVPSLNSSTSTSPLPFSRPLIDRILLTRILSPFECDAYLEDF
AAHTKPDGSKVWKKASIKEFREWIGWDIEEQVEEKGVKYIFEMWVLNQ

Options for BLAST

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Database Cross Reference

Ensembl Gene
UniGene
PDB
RefSeq XP_567366.1
Pfam PF00186