C23

General Information (Source: NCBI Gene,UniProt)

Text mining Term C23
UniProt ID WHITE_DROME
Name Protein white
Gene Names w
Taxonomy Drosophila melanogaster

General annotation

Function Part of a membrane-spanning permease system necessary for the transport of pigment precursors into pigment cells responsible for eye color. White dimerize with brown for the transport of guanine. Scarlet and white complex transports a metabolic intermediate (such as 3-hydroxy kynurenine) from the cytoplasm into the pigment granules.
Subcellular location Membrane; Multi-pass membrane protein. Cytoplasmic granule membrane; Multi-pass membrane protein. Note=Pigment granules within pigment cells and retinula cells of the compound eye (when complexed with st).

Gene Ontology

GO:0016021 integral to membrane CC
GO:0007613 memory BP
GO:0006727 ommochrome biosynthetic process BP
GO:0031409 pigment binding MF
GO:0005524 ATP binding MF
GO:0016887 ATPase activity MF
GO:0070731 cGMP transport BP
GO:0048072 compound eye pigmentation BP
GO:0004888 transmembrane signaling receptor activity MF
GO:0006856 eye pigment precursor transport BP
GO:0008049 male courtship behavior BP
GO:0042401 cellular biogenic amine biosynthetic process BP
GO:0031410 cytoplasmic vesicle CC

Sequence

>gi|7290367|gb|AAF45826.1| white [Drosophila melanogaster]
MGQEDQELLIRGGSKHPSAEHLNNGDSGAASQSCINQGFGQAKNYGTLRPPSPPEDSGSGSGQLAENLTY
AWHNMDIFGAVNQPGSGWRQLVNRTRGLFCNERHIPAPRKHLLKNVCGVAYPGELLAVMGSSGAGKTTLL
NALAFRSPQGIQVSPSGMRLLNGQPVDAKEMQARCAYVQQDDLFIGSLTAREHLIFQAMVRMPRHLTYRQ
RVARVDQVIQELSLSKCQHTIIGVPGRVKGLSGGERKRLAFASEALTDPPLLICDEPTSGLDSFTAHSVV
QVLKKLSQKGKTVILTIHQPSSELFELFDKILLMAEGRVAFLGTPSEAVDFFSYVGAQCPTNYNPADFYV
QVLAVVPGREIESRDRIAKICDNFAISKVARDMEQLLATKNLEKPLEQPENGYTYKATWFMQFRAVLWRS
WLSVLKEPLLVKVRLIQTTMVAILIGLIFLGQQLTQVGVMNINGAIFLFLTNMTFQNVFATINVFTSELP
VFMREARSRLYRCDTYFLGKTIAELPLFLTVPLVFTAIAYPMIGLRAGVLHFFNCLALVTLVANVSTSFG
YLISCASSSTSMALSVGPPVIIPFLLFGGFFLNSGSVPVYLKWLSYLSWFRYANEGLLINQWADVEPGEI
SCTSSNTTCPSSGKVILETLNFSAADLPLDYVGLAILIVSFRVLAYLALRLRARRKE

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Database Cross Reference

Ensembl Gene
UniGene Dm.19661
PDB
RefSeq NP_476787.1
Pfam PF00005
PF01061