acetylcholine receptor (protein family or complex)

General Information (Source: NCBI Gene,UniProt)

Text mining Term acetylcholine receptor (protein family or complex)
UniProt ID ACH1_MANSE
Name Acetylcholine receptor subunit alpha-like
MARA1
Gene Names ARA1
Taxonomy Manduca sexta

General annotation

Function After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane (By similarity).
Subcellular location Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein (By similarity). Cell membrane; Multi-pass membrane protein (By similarity).

Gene Ontology

GO:0005886 plasma membrane CC
GO:0045211 postsynaptic membrane CC
GO:0004872 receptor activity MF
GO:0004889 acetylcholine-activated cation-selective channel activity MF
GO:0030054 cell junction CC
GO:0016021 integral to membrane CC

Sequence

>gi|1743343|emb|CAA70928.1| nicotinic acetylcholine receptor alpha-like subunit [Manduca sexta]
MRSVTKYYLHGVVLFATGCAGNPDAKRLYDDLLSNYNKLVRPVLNVSDALTVRIKLKLSQLIDVNLKNQI
MTTNLWVEQSWYDYKLSWEPREYGGVEMLHVPSDHIWRPDIVLYNNADGNFEVTLATKATLNYTGRVEWR
PPAIYKSSCEIDVEYFPFDQQTCVMKFGSWTYDGFQVDLRHIDEVRGTNVVELGVDLSEFYTSVEWDILE
VPAVRNEKFYTCCDEPYLDITFNITMRRKTLFYTVNLIIPCMGISFLTVLVFYLPSDSGEKVSLSISILL
SLTVFFLLLAEIIPPTSLVVPLLGKFVLFTMILDTFSICVTVVVLNVHFRSPQTHTMSPWVRRVFIHVLP
RLLVMRRPHYRLDPHRSRFAGLVTGAGETTLWDEGSPGVPAPPRPPPCAPPLAPCAACAPAEAPALCDAL
RRWHRCPELHKAIDGINYIADQTRKEEESTRVKEDWKYVAMVLDRPFLWIFTLAVVVGSAGIILQAPTLY
DERAPIDVRLSEIAYTAAKPRPPPPR

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Database Cross Reference

Ensembl Gene
UniGene
PDB
RefSeq
Pfam PF02932
PF02931