| Text mining Term | PARP |
|---|---|
| UniProt ID | PARP_DROME |
| Name |
Poly[ADP-ribose] synthase Poly [ADP-ribose] polymerase NAD(+) ADP-ribosyltransferase ADPRT PARP |
| Gene Names |
Parp
|
| Taxonomy | Drosophila melanogaster |
| Function |
Poly[ADP-ribose] polymerase modifies various nuclear proteins by poly(ADP-ribosyl)ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage. Plays a fundamental role in organizing chromatin on a global scale; isoform e autoregulates Parp transcription by influencing the chromatin structure of its heterochromatic environment. |
|---|---|
| Subcellular location |
Nucleus. Nucleus, nucleolus. Note=Highly enriched in nucleoli, heterochromatic chromosomal regions, and diverse euchromatic sites in the cells of most embryonic and adult tissues. |
| GO:0005730 | nucleolus | CC |
| GO:0003950 | NAD+ ADP-ribosyltransferase activity | MF |
| GO:0035080 | heat shock-mediated polytene chromosome puffing | BP |
| GO:0005703 | polytene chromosome puff | CC |
| GO:0003677 | DNA binding | MF |
| GO:0009303 | rRNA transcription | BP |
| GO:0007552 | metamorphosis | BP |
| GO:0016568 | chromatin modification | BP |
| GO:0042393 | histone binding | MF |
| GO:0008270 | zinc ion binding | MF |
| GO:0005719 | nuclear euchromatin | CC |
| GO:0043484 | regulation of RNA splicing | BP |
| GO:0045087 | innate immune response | BP |
| GO:0006471 | protein ADP-ribosylation | BP |
| GO:0051457 | maintenance of protein location in nucleus | BP |
| GO:0007000 | nucleolus organization | BP |
| GO:0006963 | positive regulation of antibacterial peptide biosynthetic process | BP |
| GO:0006355 | regulation of transcription, DNA-dependent | BP |
| GO:0051287 | NAD binding | MF |
>gi|548585|sp|P35875.1|PARP_DROME RecName: Full=Poly [ADP-ribose] polymerase; Short=PARP; AltName: Full=NAD(+) ADP-ribosyltransferase; Short=ADPRT; AltName: Full=Poly[ADP-ribose] synthase MDIELPYLAEYARTGRATCKGCKSTISKDTLRIAVMVQSAFHDAKVPNWFHKTCFFKNQRPSSVGDIQNI GNLRFADQKELTDLVENIQEVISAQLGKKRSKAFNLALKDFGIEYAKSSRSTCRGCEQKINKDLVRLRKT VYDTEVGMKYGGQPLWHHLECFAQLRSELGWFASGEDMPGFQSLADDDQAKVKNAIPPIKSEELPDTKRA KMELSDTNEEGEKKQRLKDQNDAYFRFRDDIKNKMKKKDIDILLKFNNQQPVTGDTEKLFDQTADLLTFG AIESCSECNSCQFIVNKSGYICNGNHSEWTKCNKLLKEPTRSACIVPKELKALYNFLNTVKEIPSTRIFN NFPPNKSTFSRSLLKTNKNNDVLVRPTIPRISPPLYNLKFSIIGLKNQHKELRKRIENLGGKFEVKISEN TIAIISTELEIQKKSTRMKFAEELGIHIVPIEFLDFVEADTEGAIKYINSTCICSWGTDPKSRIPKETTK SLNSNSIYTKSMPVSRTFKVKDGLAVDPDSGLEDIAHVYVDSNNKYSVVLGLTDIQRNKNSYYKVQLLKA DKKEKYWIFRSWGRIGTNIGNSKLEEFDTSESAKRNFKEIYADKTGNEYEQRDNFVKRTGRMYPIEIQYD DDQKLVKHESHFFTSKLEISVQNLIKLIFDIDSMNKTLMEFHIDMDKMPLGKLSAHQIQSAYRVVKEIYN VLECGSNTAKLIDATNRFYTLIPHNFGVQLPTLIETHQQIEDLRQMLDSLAEIEVAYSIIKSEDVSDACN PLDNHYAQIKTQLVALDKNSEEFSILSQYVKNTHASTHKSYDLKIVDVFKVSRQGEARRFKPFKKLHNRK LLWHGSRLTNFVGILSHGLRIAPPEAPPTGYMFGKGIYFADMVSKSANYCCTSQQNSTGLMLLSEVALGD MMECTSAKYINKLSNNKHSCFGRGRTMPDPTKSYIRSDGVEIPYGETITDEHLKSSLLYNEYIVYDVAQV NIQYLFRMEFKYSY |
| Ensembl Gene | |
|---|---|
| UniGene |
Dm.7847 |
| PDB | |
| RefSeq |
NP_001104452.1 |
| Pfam |
PF00645 PF05406 PF02877 PF00644 PF00533 PF08063 |