succinate dehydrogenase (protein family or complex)

General Information (Source: NCBI Gene,UniProt)

Text mining Term succinate dehydrogenase (protein family or complex)
UniProt ID DHSA_DROME
Name FP
Flavoprotein subunit of complex II
Succinyl coenzyme A synthetase flavoprotein subunit
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial
Gene Names SdhA
Taxonomy Drosophila melanogaster

General annotation

Function Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). Maintaining electron transport chain function is required to prevent neurodegenerative changes seen in both early- and late-onset disorders.
Subcellular location Mitochondrion inner membrane; Peripheral membrane protein; Matrix side (By similarity).

Gene Ontology

GO:0050660 flavin adenine dinucleotide binding MF
GO:0008177 succinate dehydrogenase (ubiquinone) activity MF
GO:0006810 transport BP
GO:0006099 tricarboxylic acid cycle BP
GO:0009055 electron carrier activity MF
GO:0005743 mitochondrial inner membrane CC
GO:0022900 electron transport chain BP

Sequence

>gi|24655647|ref|NP_725882.1| succinate dehydrogenase A, isoform C [Drosophila melanogaster]
MSGIMRVPSILAKNAVASMQRAAAVGVQRSYHITHGRQQASAANPDKISKQYPVVDHAYDAIVVGAGGAG
LRAAFGLVAEGFRTAVITKLFPTRSHTIAAQGGINAALGNMEEDDWKWHMYDTVKGSDWLGDQDAIHYMT
REAPKAVIELENYGMPFSRTQDGKIYQRAFGGQSLKFGKGGQAHRCCAVADRTGHSLLHTLYGQSLSYDC
NYFVEYFALDLIFEDGECRGVLALNLEDGTLHRFRAKNTVIATGGYGRAFFSCTSAHTCTGDGTAMVARQ
GLPSQDLEFVQFHPTGIYGAGCLITEGCRGEGGYLINGNGERFMERYAPVAKDLASRDVVSRSMTIEIME
GRGAGPEKDHVYLQLHHLPPKQLAERLPGISETAMIFAGVDVTREPIPVLPTVHYNMGGVPTNYRGQVIT
IDKDGKDVIVPGLYAAGEAASSSVHGANRLGANSLLDLVVFGRACAKTIAELNKPGAPAPTLKENAGEAS
VANLDKLRHANGQITTADLRLKMQKTMQHHAAVFRDGPILQDGVNKMKEIYKQFKDIKVVDRSLIWNSDL
VETLELQNLLANAQMTIVSAEARKESRGAHAREDFKVREDEYDFSKPLDGQQKKPMDQHWRKHTLSWVCN
DNGDITLDYRNVIDTTLDNEVSTVPPAIRSY

Options for BLAST

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Database Cross Reference

Ensembl Gene
UniGene
PDB
RefSeq NP_725881.1
NP_477210.1
NP_725882.1
Pfam PF00890
PF02910