adrenodoxin reductase

General Information (Source: NCBI Gene,UniProt)

Text mining Term adrenodoxin reductase
UniProt ID ADRO_MOUSE
Name NADPH:adrenodoxin oxidoreductase, mitochondrial
AR
Adrenodoxin reductase
Ferredoxin--NADP(+) reductase
Ferredoxin reductase
Gene Names Fdxr
Taxonomy Mus musculus

General annotation

Function Serves as the first electron transfer protein in all the mitochondrial P450 systems. Including cholesterol side chain cleavage in all steroidogenic tissues, steroid 11-beta hydroxylation in the adrenal cortex, 25-OH-vitamin D3-24 hydroxylation in the kidney, and sterol C-27 hydroxylation in the liver.
Subcellular location Mitochondrion matrix.

Gene Ontology

GO:0004324 ferredoxin-NADP+ reductase activity MF
GO:0005759 mitochondrial matrix CC
GO:0006810 transport BP
GO:0005743 mitochondrial inner membrane CC
GO:0008203 cholesterol metabolic process BP
GO:0022900 electron transport chain BP

Sequence

>gi|6679767|ref|NP_032023.1| NADPH:adrenodoxin oxidoreductase, mitochondrial precursor [Mus musculus]
MAPRCWHWWRWSAWSGLRPSPSRSTPTPGFCQKFSTQEKTPQICVVGSGPAGFYTAQHLLKHHTHAHVDI
YEKQLVPFGLVRFGVAPDHPEVKNVINTFTQTARSDRCAFQGNVVVGRDVSVPELREAYHAVVLSYGAED
HQPLGIPGEELPGVVSARAFVGWYNGLPENQELAPDLSCDTAVILGQGNVALDVARILLTPPEHLEKTDI
TEAALGALRQSRVKTVWIVGRRGPLQVAFTIKELREMIQLPGTRPILDPSDFLGLQDRIKDVPRPRRRLT
ELLLRTATEKPGVEEAARQALASRAWGLRFFRSPQQVLPTPDGQRVAGIRLAVTSLEGVGESTRAVPTGD
VEDLPCGLLLSSVGYKSRPIDPSVPFDPKLGVIPNTEGRVVNVPGLYCSGWVKRGPTGVITTTMTDSFLT
SQALLEDLKAGLLPSGPRPGYVAIQALLSNRGVRPVSFSDWEKLDAEEVSRGQGTGKPREKLVDRREMLR
LLGH

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Database Cross Reference

Ensembl Gene ENSMUST00000021078
UniGene Mm.4719
PDB
RefSeq NP_032023.1
Pfam