adrenodoxin reductase

General Information (Source: NCBI Gene,UniProt)

Text mining Term adrenodoxin reductase
UniProt ID ADRO_RAT
Name Ferredoxin reductase
NADPH:adrenodoxin oxidoreductase, mitochondrial
AR
Adrenodoxin reductase
Ferredoxin--NADP(+) reductase
Gene Names Fdxr
Taxonomy Rattus norvegicus

General annotation

Function Serves as the first electron transfer protein in all the mitochondrial P450 systems. Including cholesterol side chain cleavage in all steroidogenic tissues, steroid 11-beta hydroxylation in the adrenal cortex, 25-OH-vitamin D3-24 hydroxylation in the kidney, and sterol C-27 hydroxylation in the liver.
Subcellular location Mitochondrion matrix.

Gene Ontology

GO:0005515 protein binding MF
GO:0070995 NADPH oxidation BP
GO:0005759 mitochondrial matrix CC
GO:0006810 transport BP
GO:0022900 electron transport chain BP
GO:0070402 NADPH binding MF
GO:0004324 ferredoxin-NADP+ reductase activity MF
GO:0015039 NADPH-adrenodoxin reductase activity MF
GO:0008203 cholesterol metabolic process BP

Sequence

>gi|13162347|ref|NP_077067.1| NADPH:adrenodoxin oxidoreductase, mitochondrial precursor [Rattus norvegicus]
MAPRCWRWWSWSAWPGVRPLPSRSTPTPGFCKKFSTQETTPQICVVGSGPAGFYTAQHLLKHHTRAHVDI
YEKQLVPFGLVRFGVAPDHPEVKNVINTFTQTARSDRCAFRGNVVVGRDVSVPELREAYHAVVLSYGAED
HQPLEIPGEELPGVVSARAFVGWYNGLPENQKLAPDLSCDTAVILGQGNVALDVARILLTPPEHLEKTDI
TEVALGVLRQSRVKTVWIVGRRGPLQVAFTIKELREMIQLPGTQPILDPSDFLGLQDRIKDVPRPRKRLT
ELLLRTATEKPGVEEAARRALASRAWGLRFFRSPQQVLPTPDGRRVAGIRLAVTRLEGVGESTRAVPTGD
VEDLPCGLLLSSVGYKSRPIDPSVPFDPKLGIIPNTEGRVVNAPGLYCSGWVKRGPTGVITTTMTDSFLT
SQVLLKDLKAGLLPSGPRPGYTAIQALLSDRGVRPVSFSDWEKLDAEEVARGQGTGKPREKLVDRREMLQ
LLGH

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Database Cross Reference

Ensembl Gene
UniGene Rn.10860
PDB
RefSeq NP_077067.1
Pfam