NK 2 receptor

General Information (Source: NCBI Gene,UniProt)

Text mining Term NK 2 receptor
UniProt ID NK2R_RAT
Name NK-2 receptor
Tachykinin receptor 2
Neurokinin A receptor
Substance-K receptor
NK-2R
SKR
Gene Names Tacr2
Synonyms:Tac2r
Taxonomy Rattus norvegicus

General annotation

Function This is a receptor for the tachykinin neuropeptide substance K (neurokinin A). It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: substance K > neuromedin-K > substance P.
Subcellular location Cell membrane; Multi-pass membrane protein.

Gene Ontology

GO:0014057 positive regulation of acetylcholine secretion BP
GO:0043117 positive regulation of vascular permeability BP
GO:0014827 intestine smooth muscle contraction BP
GO:0033685 negative regulation of luteinizing hormone secretion BP
GO:0035106 operant conditioning BP
GO:0016497 substance K receptor activity MF
GO:0005624 membrane fraction CC
GO:0070459 prolactin secretion BP
GO:0070474 positive regulation of uterine smooth muscle contraction BP
GO:0016021 integral to membrane CC
GO:0043270 positive regulation of ion transport BP
GO:0005886 plasma membrane CC
GO:0006950 response to stress BP

Sequence

>gi|18158435|ref|NP_542946.1| substance-K receptor [Rattus norvegicus]
MGTRAIVSDANILSGLESNATGVTAFSMPGWQLALWATAYLALVLVAVTGNATVIWIILAHERMRTVTNY
FIINLALADLCMAAFNATFNFIYASHNIWYFGRAFCYFQNLFPITAMFVSIYSMTAIAADRYMAIVHPFQ
PRLSAPSTKAIIAGIWLVALALASPQCFYSTITVDEGATKCVVAWPNDNGGKMLLLYHLVVFVLIYFLPL
LVMFGAYSVIGLTLWKRAVPRHQAHGANLRHLQAKKKFVKAMVLVVLTFAICWLPYHLYFILGTFQEDIY
YHKFIQQVYLALFWLAMSSTMYNPIIYCCLNHRFRSGFRLAFRCCPWVTPTEEDRLELTHTPSLSRRVNR
CHTKETLFMTGDMTHSEATNGQVGSPQDGEPAGPICKAQA

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Database Cross Reference

Ensembl Gene
UniGene Rn.202846
PDB
RefSeq NP_542946.1
Pfam PF00001