interleukin 2

General Information (Source: NCBI Gene,UniProt)

Text mining Term interleukin 2
UniProt ID IL2_MOUSE
Name IL-2
T-cell growth factor
TCGF
Interleukin-2
Gene Names Il2
Taxonomy Mus musculus

General annotation

Function Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine- activated killer cells, natural killer cells, and glioma cells.
Subcellular location Secreted.

Gene Ontology

GO:0042104 positive regulation of activated T cell proliferation BP
GO:0045944 positive regulation of transcription from RNA polymerase II promoter BP
GO:0008083 growth factor activity MF
GO:0005615 extracellular space CC
GO:0050728 negative regulation of inflammatory response BP
GO:0042523 positive regulation of tyrosine phosphorylation of Stat5 protein BP
GO:0048304 positive regulation of isotype switching to IgG isotypes BP
GO:0051024 positive regulation of immunoglobulin secretion BP
GO:0050672 negative regulation of lymphocyte proliferation BP
GO:0005134 interleukin-2 receptor binding MF
GO:0006955 immune response BP
GO:0046013 regulation of T cell homeostatic proliferation BP
GO:0005125 cytokine activity MF

Sequence

>gi|7110653|ref|NP_032392.1| interleukin-2 precursor [Mus musculus]
MYSMQLASCVTLTLVLLVNSAPTSSSTSSSTAEAQQQQQQQQQQQQHLEQLLMDLQELLSRMENYRNLKL
PRMLTFKFYLPKQATELKDLQCLEDELGPLRHVLDLTQSKSFQLEDAENFISNIRVTVVKLKGSDNTFEC
QFDDESATVVDFLRRWIAFCQSIISTSPQ

Options for BLAST

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Database Cross Reference

Ensembl Gene ENSMUST00000029275
UniGene Mm.14190
PDB
RefSeq NP_032392.1
Pfam PF00715