cytochrome P450 monooxygenase

General Information (Source: NCBI Gene,UniProt)

Text mining Term cytochrome P450 monooxygenase
UniProt ID CP2J3_RAT
Name Cytochrome P450 2J3
CYPIIJ3
Gene Names Cyp2j3
Synonyms:Cyp2j9
Taxonomy Rattus norvegicus

General annotation

Function This enzyme metabolizes arachidonic acid predominantly via a NADPH-dependent olefin epoxidation mainly to 14,15-, 11,12-, and 8,9-epoxyeicosatrienoic acids (EET). It also acts as an omega- 1-hydroxylase by metabolizing arachidonic acid to 19- hydroxyeicosatetraenoic acid (19-OH-AA).
Subcellular location Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.

Gene Ontology

GO:0020037 heme binding MF
GO:0005789 endoplasmic reticulum membrane CC
GO:0005792 microsome CC
GO:0070330 aromatase activity MF
GO:0009055 electron carrier activity MF

Sequence

>gi|28461169|ref|NP_786942.1| cytochrome P450 2J3 [Rattus norvegicus]
MLVTAGSLLGAIWTVLHLRILLLAAVTFLFLADFLKHRRPKNYPPGPWRLPLVGCLFHLDPKQPHLSLQQ
FVKKYGNVLSLDFANIPSVVVTGMPLIKEIFTQMEHNFLNRPVTLLRKHLFNKNGLIFSSGQTWKEQRRF
ALMTLRNFGLGKKSLEQRIQEEAYHLVEAIKDEGGLPFDPHFNINKAVSNIICSVTFGERFEYHDSQFQE
MLRLLDEAMCLESSMMCQLYNIFPRILQYLPGSHQTLFSNWRKLKLFISDIIKNHRRDWDPDEPRDFIDA
FLKEMAKYPDKTTTSFNEENLICSTLDLFFAGTETTSTTLRWALLCMALYPEVQEKMQAEIDRVIGQGRQ
PNLADRDSMPYTNAVIHEVQRIGNIIPFNVPREVAVDTYLAGFNLPKGTMILTNLTALHRDPKEWATPDT
FNPEHFLENGQFKKRESFLPFSMGKRACLGEQLARSELFIFITSLIQKFTFKPPVNEKLSLQFRMSVTIS
PVSHRLCAIPRL

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Database Cross Reference

Ensembl Gene
UniGene Rn.91314
PDB
RefSeq NP_786942.1
Pfam PF00067