cystathionine gamma lyase

General Information (Source: NCBI Gene,UniProt)

Text mining Term cystathionine gamma lyase
UniProt ID CGL_MOUSE
Name Cystathionine gamma-lyase
Gamma-cystathionase
Gene Names Cth
Taxonomy Mus musculus

General annotation

Function Catalyzes the last step in the transsulfuration pathway from methionine to cysteine. Has broad substrate specificity. Converts cystathionine to cysteine, ammonia and 2-oxobutanoate. Converts two cysteine molecules to lanthionine and hydrogen sulfide. Can also accept homocysteine as substrate. Specificity depends on the levels of the endogenous substrates. Generates the endogenous signaling molecule hydrogen sulfide (H2S), and so contributes to the regulation of blood pressure.
Subcellular location Cytoplasm (By similarity).

Gene Ontology

GO:0005737 cytoplasm CC
GO:0019344 cysteine biosynthetic process BP
GO:0018272 protein-pyridoxal-5-phosphate linkage via peptidyl-N6-pyridoxal phosphate-L-lysine BP
GO:0070814 hydrogen sulfide biosynthetic process BP
GO:0004123 cystathionine gamma-lyase activity MF
GO:0080146 L-cysteine desulfhydrase activity MF
GO:0030170 pyridoxal phosphate binding MF

Sequence

>gi|22122387|ref|NP_666065.1| cystathionine gamma-lyase [Mus musculus]
MQKDASLSGFLPSFQHFATQAIHVGQEPEQWNSRAVVLPISLATTFKQDFPGQSSGFEYSRSGNPTRNCL
EKAVAALDGAKHSLAFASGLAATITITHLLKAGDEIICMDEVYGGTNRYFRRVASEFGLKISFVDCSKTK
LLEAAITPQTKLVWIETPTNPTLKLADIGACAQIVHKRGDIILVVDNTFMSAYFQRPLALGADICMCSAT
KYMNGHSDVVMGLVSVNSDDLNSRLRFLQNSLGAVPSPFDCYLCCRGLKTLQVRMEKHFKNGMAVARFLE
TNPRVEKVVYPGLPSHPQHELAKRQCSGCPGMVSFYIKGALQHAKAFLKNLKLFTLAESLGGYESLAELP
AIMTHASVPEKDRATLGINDTLIRLSVGLEDEQDLLEDLDRALKAAHP

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Database Cross Reference

Ensembl Gene ENSMUST00000118539
UniGene Mm.28301
PDB
RefSeq NP_666065.1
Pfam PF01053