brain derived neurotrophic factor

General Information (Source: NCBI Gene,UniProt)

Text mining Term brain derived neurotrophic factor
UniProt ID BDNF_MOUSE
Name BDNF
Brain-derived neurotrophic factor
Gene Names Bdnf
Taxonomy Mus musculus

General annotation

Function During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS.
Subcellular location Secreted.

Gene Ontology

GO:0007406 negative regulation of neuroblast proliferation BP
GO:0016023 cytoplasmic membrane-bounded vesicle CC
GO:0021675 nerve development BP
GO:0008038 neuron recognition BP
GO:0042596 fear response BP
GO:0045666 positive regulation of neuron differentiation BP
GO:0016358 dendrite development BP
GO:0007412 axon target recognition BP
GO:0007411 axon guidance BP
GO:0005576 extracellular region CC
GO:0008083 growth factor activity MF
GO:0001657 ureteric bud development BP
GO:0006916 anti-apoptosis BP
GO:0019222 regulation of metabolic process BP
GO:0014047 glutamate secretion BP
GO:0042493 response to drug BP
GO:0007631 feeding behavior BP
GO:0048839 inner ear development BP
GO:0046668 regulation of retinal cell programmed cell death BP
GO:0007611 learning or memory BP
GO:0043524 negative regulation of neuron apoptosis BP
GO:0005788 endoplasmic reticulum lumen CC
GO:0048167 regulation of synaptic plasticity BP

Sequence

>gi|114326461|ref|NP_001041606.1| brain-derived neurotrophic factor isoform 2 precursor [Mus musculus]
MTILFLTMVISYFGCMKAAPMKEVNVHGQGNLAYPGVRTHGTLESVNGPRAGSRGLTTTSLADTFEHVIE
ELLDEDQKVRPNEENHKDADLYTSRVMLSSQVPLEPPLLFLLEEYKNYLDAANMSMRVRRHSDPARRGEL
SVCDSISEWVTAADKKTAVDMSGGTVTVLEKVPVSKGQLKQYFYETKCNPMGYTKEGCRGIDKRHWNSQC
RTTQSYVRALTMDSKKRIGWRFIRIDTSCVCTLTIKRGR

Options for BLAST

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Database Cross Reference

Ensembl Gene ENSMUST00000111050
ENSMUST00000111042
ENSMUST00000111049
ENSMUST00000111047
ENSMUST00000111045
ENSMUST00000111044
ENSMUST00000111046
ENSMUST00000111051
ENSMUST00000111043
UniGene Mm.1442
PDB
RefSeq NP_001041606.1
NP_001041604.1
NP_001041607.1
Pfam PF00243