NR4

General Information (Source: NCBI Gene,UniProt)

Text mining Term NR4
UniProt ID NMD3B_MOUSE
Name Nr4
Glutamate [NMDA] receptor subunit 3B
NMDAR3B
N-methyl-D-aspartate receptor subunit NR3B
NMDA receptor 4
NR3B
Gene Names Grin3b
Taxonomy Mus musculus

General annotation

Function NMDA receptor subtype of glutamate-gated ion channels with reduced single-channel conductance, low calcium permeability and low voltage-dependent sensitivity to magnesium. Mediated by glycine.
Subcellular location Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane. Note=Requires the presence of GRIN1 to be targeted at the plasma membrane.

Gene Ontology

GO:0051205 protein insertion into membrane BP
GO:0030054 cell junction CC
GO:0045211 postsynaptic membrane CC
GO:0051924 regulation of calcium ion transport BP
GO:0017146 N-methyl-D-aspartate selective glutamate receptor complex CC
GO:0070588 calcium ion transmembrane transport BP
GO:0004970 ionotropic glutamate receptor activity MF
GO:0005234 extracellular-glutamate-gated ion channel activity MF
GO:0030288 outer membrane-bounded periplasmic space CC
GO:0043025 neuronal cell body CC

Sequence

>gi|20127397|ref|NP_569722.1| glutamate [NMDA] receptor subunit 3B precursor [Mus musculus]
MECVQTLWLSLALALARGSWVVRGHPQPCGVPTRAGASVRLAALLPRAPAARARVLAALATPSPRLPHNL
SLELVAVASPTRDPASLARGLCQVLAPPGVVASITFPEARPELRLLQFLAAATETPVLSVLRREVRAPLG
APTPFHLQLDWASPLETILDVLVSLVRAHAWEDIALVLCRVRDPSGLVTLWTSRASQAPKFVLDLSQLDS
GNDSLRATLALLGTLEGGGTPVSAAVLLGCSTAHAHEVLEAAPPGPQWLLGTPLPAEALPKTGLPPGVLV
LGETGQPSLEAAVHDMVELVARALSSMALMHPERALLPAAVNCEDLKTGGSESTARTLARFLSNTSFQGR
TGAVWVAGSSQVHVSRHFKVWSLRRDPLGAPAWATVGSWQDGQLDFQPGAAALRVPSPSGTQARPKLRVV
TLVEHPFVFTRESDEDGQCPAGQLCLDPGTNDSARLDALFTALENGSVPRTLRRCCYGYCIDLLERLAED
LAFDFELYIVGDGKYGALRDGRWTGLVGDLLAGRAHMAVTSFSINSARSQVVDFTSPFFSTSLGIMVRTR
DTASPIGAFMWPLHWSMWVGVFAALHLTALFLTLYEWRSPYGLTPRGRNRGTVFSYSSALNLCYAILFGR
TVSSKTPKCPTGRFLMNLWAIFCLLVLSSYTANLAAVMVGDKTFEELSGIHDPKLHHPSQGFRFGTVWES
SAEAYIKASFPEMHAHMRRHSAPTTPHGVAMLTSDPPKLNAFIMDKSLLDYEVSIDADCKLLTVGKPFAI
EGYGIGLPQNSPLTSNLSEFISRYKSSGFIDLLHDKWYKMVPCGKRVFAVTETLQMGVYHLSGLFVLLCL
GLGSALLTSLGEHVFYRLVLPRIRRGNKLQYWLHTSQKIHRALNTGPPEGQQERAEQECSGPKEEQPAAD
GAGRWRRVRRAVVERERRVRFLLEPGEAGGDHPWLCSNGPGVQAELRELELRIEAARERLRSALLRRGEL
RAQLGDGTRLRPLRLLHAAPAES

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Database Cross Reference

Ensembl Gene ENSMUST00000045085
UniGene Mm.391566
PDB
RefSeq NP_569722.1
Pfam PF00060
PF00497