serine racemase

General Information (Source: NCBI Gene,UniProt)

Text mining Term serine racemase
UniProt ID SRR_RAT
Name L-serine ammonia-lyase
D-serine ammonia-lyase
Serine racemase
L-serine dehydratase
D-serine dehydratase
Gene Names Srr
Taxonomy Rattus norvegicus

General annotation

Function Catalyzes the synthesis of D-serine from L-serine. D- serine is a key coagonist with glutamate at NMDA receptors. Has dehydratase activity towards both L-serine and D-serine.
Subcellular location

Gene Ontology

GO:0045177 apical part of cell CC
GO:0003941 L-serine ammonia-lyase activity MF
GO:0005524 ATP binding MF
GO:0005886 plasma membrane CC
GO:0030378 serine racemase activity MF
GO:0007420 brain development BP
GO:0005737 cytoplasm CC
GO:0008721 D-serine ammonia-lyase activity MF
GO:0030170 pyridoxal phosphate binding MF
GO:0043278 response to morphine BP
GO:0042493 response to drug BP
GO:0000287 magnesium ion binding MF
GO:0006563 L-serine metabolic process BP
GO:0007568 aging BP
GO:0042803 protein homodimerization activity MF

Sequence

>gi|38454254|ref|NP_942052.1| serine racemase [Rattus norvegicus]
MCAQYCISFADVEKAHLNIQDSVHLTPVLTSSILNQIAGRNLFFKCELFQKTGSFKIRGALNAIRGLIPD
TLEGKPKAVVTHSSGNHGQALTYAAKLEGIPAYIVVPQTAPNCKKLAIQAYGASIVYSEPSDESRENVAQ
RIIQETEGILVHPNQEPAVIAGQGTIALEVLNQVPLVDALVVPVGGGGMVAGIAITIKTLKPSVKVYAAE
PSNADDCYQSKLKGELTPNLHPPETIADGVKSSIGLNTWPIIRDLVDDVFTVTEDEIKYATQLVWERMKL
LIEPTAGVGLAAVLSQHFQTVSPEVKNICIVLSGGNVDLTSLSWVKQAERPAP

Options for BLAST

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Database Cross Reference

Ensembl Gene ENSRNOT00000046110
UniGene Rn.220332
PDB 3HMK
3L6C
RefSeq NP_942052.1
Pfam PF00291