Ciliary neurotrophic factor

General Information (Source: NCBI Gene,UniProt)

Text mining Term Ciliary neurotrophic factor
UniProt ID CNTF_MOUSE
Name CNTF
Ciliary neurotrophic factor
Gene Names Cntf
Taxonomy Mus musculus

General annotation

Function CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy.
Subcellular location Cytoplasm.

Gene Ontology

GO:0046668 regulation of retinal cell programmed cell death BP
GO:0046533 negative regulation of photoreceptor cell differentiation BP
GO:0048666 neuron development BP
GO:0008083 growth factor activity MF
GO:0040007 growth BP
GO:0042517 positive regulation of tyrosine phosphorylation of Stat3 protein BP
GO:0005615 extracellular space CC
GO:0048644 muscle organ morphogenesis BP

Sequence

>gi|25952141|ref|NP_740756.1| ciliary neurotrophic factor [Mus musculus]
MAFAEQSPLTLHRRDLCSRSIWLARKIRSDLTALMESYVKHQGLNKNISLDSVDGVPVASTDRWSEMTEA
ERLQENLQAYRTFQGMLTKLLEDQRVHFTPTEGDFHQAIHTLTLQVSAFAYQLEELMALLEQKVPEKEAD
GMPVTIGDGGLFEKKLWGLKVLQELSQWTVRSIHDLRVISSHHMGISAHESHYGAKQM

Options for BLAST

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Database Cross Reference

Ensembl Gene ENSMUST00000112933
UniGene Mm.290924
PDB
RefSeq NP_740756.1
Pfam PF01110