Ciliary neurotrophic factor

General Information (Source: NCBI Gene,UniProt)

Text mining Term Ciliary neurotrophic factor
UniProt ID CNTF_RAT
Name CNTF
Ciliary neurotrophic factor
Gene Names Cntf
Taxonomy Rattus norvegicus

General annotation

Function CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy.
Subcellular location Cytoplasm.

Gene Ontology

GO:0043526 neuroprotection BP
GO:0008284 positive regulation of cell proliferation BP
GO:0043410 positive regulation of MAPKKK cascade BP
GO:0005127 ciliary neurotrophic factor receptor binding MF
GO:0042517 positive regulation of tyrosine phosphorylation of Stat3 protein BP
GO:0007259 JAK-STAT cascade BP
GO:0060075 regulation of resting membrane potential BP
GO:0030424 axon CC
GO:0043524 negative regulation of neuron apoptosis BP
GO:0005125 cytokine activity MF
GO:0032838 cell projection cytoplasm CC
GO:0030307 positive regulation of cell growth BP
GO:0043025 neuronal cell body CC
GO:0005634 nucleus CC
GO:0048143 astrocyte activation BP
GO:0014068 positive regulation of phosphatidylinositol 3-kinase cascade BP
GO:0005829 cytosol CC
GO:0040007 growth BP
GO:0048680 positive regulation of axon regeneration BP
GO:0008083 growth factor activity MF
GO:0046887 positive regulation of hormone secretion BP
GO:0060081 membrane hyperpolarization BP

Sequence

>gi|6978675|ref|NP_037298.1| ciliary neurotrophic factor [Rattus norvegicus]
MAFAEQTPLTLHRRDLCSRSIWLARKIRSDLTALMESYVKHQGLNKNINLDSVDGVPVASTDRWSEMTEA
ERLQENLQAYRTFQGMLTKLLEDQRVHFTPTEGDFHQAIHTLMLQVSAFAYQLEELMVLLEQKIPENEAD
GMPATVGDGGLFEKKLWGLKVLQELSQWTVRSIHDLRVISSHQMGISALESHYGAKDKQM

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Database Cross Reference

Ensembl Gene
UniGene Rn.6067
PDB
RefSeq NP_037298.1
Pfam PF01110