guanine nucleotide exchange factor

General Information (Source: NCBI Gene,UniProt)

Text mining Term guanine nucleotide exchange factor
UniProt ID RPGF5_RAT
Name M-Ras-regulated Rap GEF
rMR-GEF
MR-GEF
Rap guanine nucleotide exchange factor 5
Gene Names Rapgef5
Synonyms:Mrgef
Taxonomy Rattus norvegicus

General annotation

Function Guanine nucleotide exchange factor (GEF) for RAP1A, RAP2A and MRAS/M-Ras-GTP. Its association with MRAS inhibits Rap1 activation (By similarity).
Subcellular location Nucleus (By similarity).

Gene Ontology

GO:0007264 small GTPase mediated signal transduction BP
GO:0051056 regulation of small GTPase mediated signal transduction BP
GO:0005634 nucleus CC
GO:0005085 guanyl-nucleotide exchange factor activity MF

Sequence

>gi|114145606|ref|NP_001041380.1| rap guanine nucleotide exchange factor 5 [Rattus norvegicus]
MGSSRLRVFDPPLERKDSAALSERQLPLPTFDVPYFKYIDEEDEDDEWGSRSQSSTEDDSVDSLLSDRYV
VVSGTPEKILEHLLNDLHLAEVQHKETETLLDDFLLTYTVFMTTDDLCQALLRHYSAKKYQGEEENSDVP
CRKRKVLHLVSQWISLYKDWLHEDEHSKMFLKTIYRNVLDDVYEYPILEKELKEFQKILGMHRRHTVDEY
SPQKKNKALFHQFSLKENWLQHRGTVAETEEIFCHVYVTEHSYISVKAKVSSTAQEILKVVAEKLQRAEE
DLALVAIMFSGEKHEFQPNDLAISKSLEASGRIYVYRKDLADTLNPFAENEESQQRSMRILGMNTWDLAL
ELMSFDWSLFNSIHEQELIYFTFSRQGSGEHTVNLSLLLQRCNEVQLWVATEILLCSQLGKRVQLVKKFI
KIAAHCKAQQNLNSFFAIVMGLNTASVSRLSQTWEKIPGKFKKLFSELESLTDPSLNHKAYRDAFKKMKP
PKIPFMPLLLKDVTFIHEGNKTFLDNLVNFEKLHMIADTVRTLRHCRTNQFGSDMSPKEQQELKSYVNHL
YVIDSQQALFELSHRLEPRA

Options for BLAST

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Database Cross Reference

Ensembl Gene
UniGene Rn.22381
PDB
RefSeq NP_001041380.1
Pfam PF00617
PF00618