metabotropic glutamate receptor 4

General Information (Source: NCBI Gene,UniProt)

Text mining Term metabotropic glutamate receptor 4
UniProt ID GRM4_RAT
Name mGluR4
Metabotropic glutamate receptor 4
Gene Names Grm4
Taxonomy Rattus norvegicus

General annotation

Function Receptor for glutamate. The activity of this receptor is mediated by a G-protein that inhibits adenylate cyclase activity.
Subcellular location Cell membrane; Multi-pass membrane protein.

Gene Ontology

GO:0043195 terminal button CC
GO:0043066 negative regulation of apoptotic process BP
GO:0043198 dendritic shaft CC
GO:0035249 synaptic transmission, glutamatergic BP
GO:0051932 synaptic transmission, GABAergic BP
GO:0008285 negative regulation of cell proliferation BP
GO:0050805 negative regulation of synaptic transmission BP
GO:0031175 neuron projection development BP
GO:0043526 neuroprotection BP
GO:0014051 gamma-aminobutyric acid secretion BP
GO:0016021 integral to membrane CC
GO:0048787 presynaptic active zone membrane CC
GO:0005886 plasma membrane CC
GO:0004930 G-protein coupled receptor activity MF

Sequence

>gi|12083595|ref|NP_073157.1| metabotropic glutamate receptor 4 precursor [Rattus norvegicus]
MSGKGGWAWWWARLPLCLLLSLYAPWVPSSLGKPKGHPHMNSIRIDGDITLGGLFPVHGRGSEGKACGEL
KKEKGIHRLEAMLFALDRINNDPDLLPNITLGARILDTCSRDTHALEQSLTFVRALIEKDGTEVRCGSGG
PPIITKPERVVGVIGASGSSVSIMVANILRLFKIPQISYASTAPDLSDNSRYDFFSRVVPSDTYQAQAMV
DIVRALKWNYVSTLASEGSYGESGVEAFIQKSRENGGVCIAQSVKIPREPKTGEFDKIIKRLLETSNARG
IIIFANEDDIRRVLEAARRANQTGHFFWMGSDSWGSKSAPVLRLEEVAEGAVTILPKRMSVRGFDRYFSS
RTLDNNRRNIWFAEFWEDNFHCKLSRHALKKGSHIKKCTNRERIGQDSAYEQEGKVQFVIDAVYAMGHAL
HAMHRDLCPGRVGLCPRMDPVDGTQLLKYIRNVNFSGIAGNPVTFNENGDAPGRYDIYQYQLRNGSAEYK
VIGSWTDHLHLRIERMQWPGSGQQLPRSICSLPCQPGERKKTVKGMACCWHCEPCTGYQYQVDRYTCKTC
PYDMRPTENRTSCQPIPIVKLEWDSPWAVLPLFLAVVGIAATLFVVVTFVRYNDTPIVKASGRELSYVLL
AGIFLCYATTFLMIAEPDLGTCSLRRIFLGLGMSISYAALLTKTNRIYRIFEQGKRSVSAPRFISPASQL
AITFILISLQLLGICVWFVVDPSHSVVDFQDQRTLDPRFARGVLKCDISDLSLICLLGYSMLLMVTCTVY
AIKTRGVPETFNEAKPIGFTMYTTCIVWLAFIPIFFGTSQSADKLYIQTTTLTVSVSLSASVSLGMLYMP
KVYIILFHPEQNVPKRKRSLKAVVTAATMSNKFTQKGNFRPNGEAKSELCENLETPALATKQTYVTYTNH
AI

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Database Cross Reference

Ensembl Gene
UniGene Rn.89046
PDB
RefSeq NP_073157.1
Pfam PF07562
PF01094
PF00003