glutathione S transferase

General Information (Source: NCBI Gene,UniProt)

Text mining Term glutathione S transferase
UniProt ID HPGDS_MOUSE
Name H-PGDS
Hematopoietic prostaglandin D synthase
Prostaglandin-H2 D-isomerase
Glutathione-dependent PGD synthase
Glutathione S-transferase
Glutathione-requiring prostaglandin D synthase
GST class-sigma
Gene Names Hpgds
Taxonomy Mus musculus

General annotation

Function Bifunctional enzyme which catalyzes both the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation, and the conjugation of glutathione with a wide range of aryl halides and organic isothiocyanates. Also exhibits low glutathione-peroxidase activity.
Subcellular location Cytoplasm.

Gene Ontology

GO:0000287 magnesium ion binding MF
GO:0004364 glutathione transferase activity MF
GO:0004667 prostaglandin-D synthase activity MF
GO:0001516 prostaglandin biosynthetic process BP
GO:0005509 calcium ion binding MF
GO:0005737 cytoplasm CC

Sequence

>gi|254281300|ref|NP_062328.3| hematopoietic prostaglandin D synthase [Mus musculus]
MPNYKLLYFNMRGRAEIIRYIFAYLDIKYEDHRIEQADWPKIKPTLPFGKIPVLEVEGLTIHQSLAIARY
LTKNTDLAGKTALEQCQADAVVDTLDDFMSLFPWAEKDQDLKERMFNELLTHQAPRLLKDLDTYLGDKEW
FIGNYVTWADFYWDICSTTLLVLKPGLLDIYPKLVSLRNKVQAIPAISAWILKRPQTKL

Options for BLAST

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Database Cross Reference

Ensembl Gene ENSMUST00000031982
UniGene Mm.410688
PDB
RefSeq NP_062328.3
Pfam PF02798
PF00043