androgen receptor

General Information (Source: NCBI Gene,UniProt)

Text mining Term androgen receptor
UniProt ID ANDR_MOUSE
Name Dihydrotestosterone receptor
Androgen receptor
Nuclear receptor subfamily 3 group C member 4
Gene Names Ar
Synonyms:Nr3c4
Taxonomy Mus musculus

General annotation

Function Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins. Transcription activation is down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3 (By similarity).
Subcellular location Nucleus. Cytoplasm (By similarity). Note=Predominantly cytoplasmic in unliganded form but translocates to the nucleus upon ligand-binding. Can also translocate to the nucleus in unliganded form in the presence of GNB2L1 (By similarity).

Gene Ontology

GO:0045720 negative regulation of integrin biosynthetic process BP
GO:0008284 positive regulation of cell proliferation BP
GO:0048638 regulation of developmental growth BP
GO:0000790 nuclear chromatin CC
GO:0048645 organ formation BP
GO:0019899 enzyme binding MF
GO:0005737 cytoplasm CC
GO:0060740 prostate gland epithelium morphogenesis BP
GO:0003706 ligand-regulated transcription factor activity MF
GO:0060571 morphogenesis of an epithelial fold BP
GO:0004882 androgen receptor activity MF
GO:0060599 lateral sprouting involved in mammary gland duct morphogenesis BP
GO:0060749 mammary gland alveolus development BP
GO:0060742 epithelial cell differentiation involved in prostate gland development BP
GO:0043066 negative regulation of apoptotic process BP
GO:0006351 transcription, DNA-dependent BP
GO:0042327 positive regulation of phosphorylation BP
GO:0008270 zinc ion binding MF
GO:0008013 beta-catenin binding MF
GO:0070974 POU domain binding MF
GO:0003700 sequence-specific DNA binding transcription factor activity MF
GO:0060736 prostate gland growth BP
GO:0043410 positive regulation of MAPKKK cascade BP
GO:0050790 regulation of catalytic activity BP
GO:0090003 regulation of establishment of protein localization in plasma membrane BP
GO:0008584 male gonad development BP
GO:0060520 activation of prostate induction by androgen receptor signaling pathway BP
GO:0043568 positive regulation of insulin-like growth factor receptor signaling pathway BP
GO:0001701 in utero embryonic development BP
GO:0060685 regulation of prostatic bud formation BP
GO:0033148 positive regulation of estrogen receptor signaling pathway BP
GO:0044212 transcription regulatory region DNA binding MF
GO:0045944 positive regulation of transcription from RNA polymerase II promoter BP
GO:0051092 positive regulation of NF-kappaB transcription factor activity BP
GO:0050680 negative regulation of epithelial cell proliferation BP
GO:0034339 regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor BP
GO:0019102 male somatic sex determination BP
GO:0048808 male genitalia morphogenesis BP
GO:0060748 tertiary branching involved in mammary gland duct morphogenesis BP
GO:0043565 sequence-specific DNA binding MF

Sequence

>gi|7304901|ref|NP_038504.1| androgen receptor [Mus musculus]
MEVQLGLGRVYPRPPSKTYRGAFQNLFQSVREAIQNPGPRHPEAANIAPPGACLQQRQETSPRRRRRQQH
TEDGSPQAHIRGPTGYLALEEEQQPSQQQAASEGHPESSCLPEPGAATAPGKGLPQQPPAPPDQDDSAAP
STLSLLGPTFPGLSSCSADIKDILNEAGTMQLLQQQQQQQQHQQQHQQHQQQQEVISEGSSARAREATGA
PSSSKDSYLGGNSTISDSAKELCKAVSVSMGLGVEALEHLSPGEQLRGDCMYASLLGGPPAVRPTPCAPL
PECKGLPLDEGPGKSTEETAEYSSFKGGYAKGLEGESLGCSGSSEAGSSGTLEIPSSLSLYKSGALDEAA
AYQNRDYYNFPLALSGPPHPPPPTHPHARIKLENPLDYGSAWAAAAAQCRYGDLGSLHGGSVAGPSTGSP
PATTSSSWHTLFTAEEGQLYGPGGGGGSSSPSDAGPVAPYGYTRPPQGLTSQESDYSASEVWYPGGVVNR
VPYPSPNCVKSEMGPWMENYSGPYGDMRLDSTRDHVLPIDYYFPPQKTCLICGDEASGCHYGALTCGSCK
VFFKRAAEGKQKYLCASRNDCTIDKFRRKNCPSCRLRKCYEAGMTLGARKLKKLGNLKLQEEGENSNAGS
PTEDPSQKMTVSHIEGYECQPIFLNVLEAIEPGVVCAGHDNNQPDSFAALLSSLNELGERQLVHVVKWAK
ALPGFRNLHVDDQMAVIQYSWMGLMVFAMGWRSFTNVNSRMLYFAPDLVFNEYRMHKSRMYSQCVRMRHL
SQEFGWLQITPQEFLCMKALLLFSIIPVDGLKNQKFFDELRMNYIKELDRIIACKRKNPTSCSRRFYQLT
KLLDSVQPIARELHQFTFDLLIKSHMVSVDFPEMMAEIISVQVPKILSGKVKPIYFHTQ

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Database Cross Reference

Ensembl Gene ENSMUST00000052837
UniGene Mm.39005
Mm.439657
Mm.394224
PDB 2QPY
RefSeq NP_038504.1
Pfam PF00105
PF00104
PF02166