cis 4

General Information (Source: NCBI Gene,UniProt)

Text mining Term cis 4
UniProt ID SOCS6_MOUSE
Name SOCS-4
Suppressor of cytokine signaling 4
CIS-4
Cytokine-inducible SH2 protein 4
SOCS-6
Suppressor of cytokine signaling 6
Gene Names Socs6
Taxonomy Mus musculus

General annotation

Function SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. May be a substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Regulates KIT degradation by ubiquitination of the tyrosine-phosphorylated receptor (By similarity).
Subcellular location

Gene Ontology

GO:0005515 protein binding MF
GO:0035556 intracellular signal transduction BP
GO:0040008 regulation of growth BP
GO:0009968 negative regulation of signal transduction BP

Sequence

>gi|31543755|ref|NP_061291.2| suppressor of cytokine signaling 6 [Mus musculus]
MKKISLKTFRKSFNLSKSKDETEFMVVQPQSLAGDFVKDDSLFGSCYGKDMASCDIGSEDEKGKNRSKSE
SLMGTLKRRLSAKQKTKGKGGTASTDEDTFSSASAPGGLKDVRAPRPIRSTSLRSHHYSPTPWPLRPTSS
EETCIKMEMRVKALVHAASPGPVNGVRKDLRELQPRELRDLQPEPRPESRCSPSSPGDLSLHLEEHVPVV
IGLMSQDYLQYTVPLDDGMCPLEGPRSCCLDTSSPMEVSAVPLPGASGAFSEDDSHVDQDLVVGPEILVD
SSVNNLLIGTTGVMLQSPRGGHDDAPPLSPLLPPMQNNPIQRNFSGLSGPDLHMAESVRCHLNFDPNSAP
GVARVYDSVQSSGPMVVTSLTEELKKLAKQGWYWGPITRWEAEGKLANVPDGSFLVRDSSDDRYLLSLSF
RSHGKTLHTRIEHSNGRFSFYEQPDVEGHTSIVDLIEHSIRDSENGAFCYSRSRLPGSATYPVRLTNPVS
RFMQVRSLQYLCRFVIRQYTRIDLIQKLPLPNKMKDYLQEKHY

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Database Cross Reference

Ensembl Gene ENSMUST00000125362
ENSMUST00000123826
ENSMUST00000070116
UniGene Mm.476577
Mm.91920
PDB
RefSeq NP_061291.2
Pfam PF07525
PF00017