dihydrofolate reductase

General Information (Source: NCBI Gene,UniProt)

Text mining Term	dihydrofolate reductase
UniProt ID	DYR_ECOLI
Name	Dihydrofolate reductase
Gene Names	folA Synonyms:tmrA
Taxonomy	Escherichia coli K-12

General annotation

Function	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.
Subcellular location

Gene Ontology

GO:0031427	response to methotrexate	BP
GO:0004146	dihydrofolate reductase activity	MF
GO:0006545	glycine biosynthetic process	BP
GO:0050661	NADP binding	MF
GO:0009257	10-formyltetrahydrofolate biosynthetic process	BP
GO:0046677	response to antibiotic	BP
GO:0006730	one-carbon metabolic process	BP
GO:0009165	nucleotide biosynthetic process	BP
GO:0042493	response to drug	BP

Sequence

>gi|16128042|ref|NP_414590.1| dihydrofolate reductase [Escherichia coli str. K-12 substr. MG1655]
MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIILSSQPGTDD
RVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGDTHFPDYEPDDWESVFSEF
HDADAQNSHSYCFEILERR

Database Cross Reference

Ensembl Gene
UniGene
PDB	1RF7 1RX7 1RX8 4DFR 2ANQ 1DYI 1RA9 7DFR 1RD7 1DRA 1DHJ 1RX1 2D0K 1RA2 1DYJ 1DHI 2DRC 2ANO 3DRC 1DRE 1RX9 1RX5 1RX2 3K74 1RX4 1RG7 1DDR 1JOM 1RE7 1RA8 1DDS 5DFR 1TDR 1RB2 6DFR 1DRH 1DRB 3OCH 1RX3 1RB3 1DYH 3DAU 2INQ 1RX6 3QL3 1RA3 3KFY 1RA1 1JOL 1RH3 1RC4
RefSeq	NP_414590.1
Pfam	PF00186

PTID

dihydrofolate reductase

General Information (Source: NCBI Gene,UniProt)

General annotation

Gene Ontology

Sequence

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Database Cross Reference