| Text mining Term | dihydrofolate reductase |
|---|---|
| UniProt ID | DYR_ECOLI |
| Name |
Dihydrofolate reductase |
| Gene Names |
folA
Synonyms:tmrA |
| Taxonomy | Escherichia coli K-12 |
| Function |
Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. |
|---|---|
| Subcellular location |
| GO:0042493 | response to drug | BP |
| GO:0006545 | glycine biosynthetic process | BP |
| GO:0031427 | response to methotrexate | BP |
| GO:0050661 | NADP binding | MF |
| GO:0004146 | dihydrofolate reductase activity | MF |
| GO:0046677 | response to antibiotic | BP |
| GO:0009257 | 10-formyltetrahydrofolate biosynthetic process | BP |
| GO:0006730 | one-carbon metabolic process | BP |
| GO:0009165 | nucleotide biosynthetic process | BP |
>gi|16128042|ref|NP_414590.1| dihydrofolate reductase [Escherichia coli str. K-12 substr. MG1655] MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIILSSQPGTDD RVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGDTHFPDYEPDDWESVFSEF HDADAQNSHSYCFEILERR |
| Ensembl Gene | |
|---|---|
| UniGene | |
| PDB |
6DFR 1DHI 1DYI 1DYJ 3DAU 2INQ 3OCH 1JOL 1RX6 2DRC 1RX8 4DFR 5DFR 3DRC 1RE7 1DDS 1DYH 1RG7 1DHJ 1RB3 2ANO 1DDR 1RX3 1RX1 1RA8 3QL3 1RA9 2D0K 1RA1 1RC4 3KFY 1RX4 1RA3 1DRE 1RH3 1RX5 2ANQ 7DFR 1RF7 1RA2 1DRH 1DRB 1RB2 1DRA 1RX2 1RD7 1RX7 1JOM 1TDR 1RX9 3K74 |
| RefSeq |
NP_414590.1 |
| Pfam |
PF00186 |