| Text mining Term | dihydrofolate reductase |
|---|---|
| UniProt ID | DYR_ECOLI |
| Name |
Dihydrofolate reductase |
| Gene Names |
folA
Synonyms:tmrA |
| Taxonomy | Escherichia coli K-12 |
| Function |
Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. |
|---|---|
| Subcellular location |
| GO:0004146 | dihydrofolate reductase activity | MF |
| GO:0009165 | nucleotide biosynthetic process | BP |
| GO:0006730 | one-carbon metabolic process | BP |
| GO:0042493 | response to drug | BP |
| GO:0050661 | NADP binding | MF |
| GO:0009257 | 10-formyltetrahydrofolate biosynthetic process | BP |
| GO:0046677 | response to antibiotic | BP |
| GO:0031427 | response to methotrexate | BP |
| GO:0006545 | glycine biosynthetic process | BP |
>gi|16128042|ref|NP_414590.1| dihydrofolate reductase [Escherichia coli str. K-12 substr. MG1655] MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIILSSQPGTDD RVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGDTHFPDYEPDDWESVFSEF HDADAQNSHSYCFEILERR |
| Ensembl Gene | |
|---|---|
| UniGene | |
| PDB |
1RX8 3K74 1RX4 4DFR 1RD7 1RA1 1RB3 1DDR 2D0K 3DAU 2DRC 1DHJ 1RF7 1RB2 3QL3 1DRB 3KFY 1RE7 1RX9 2ANO 1RA2 1RX1 7DFR 1RX3 1DRA 1DYH 1RH3 1DYI 3DRC 1RA3 1DRE 3OCH 5DFR 1RX6 1DRH 1DHI 1RG7 1RC4 1RX2 1RA8 1DYJ 1JOM 1RX5 1DDS 6DFR 1TDR 2INQ 1JOL 1RA9 2ANQ 1RX7 |
| RefSeq |
NP_414590.1 |
| Pfam |
PF00186 |