dihydrofolate reductase

General Information (Source: NCBI Gene,UniProt)

Text mining Term	dihydrofolate reductase
UniProt ID	DYR_ECOLI
Name	Dihydrofolate reductase
Gene Names	folA Synonyms:tmrA
Taxonomy	Escherichia coli K-12

General annotation

Function	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.
Subcellular location

Gene Ontology

GO:0009257	10-formyltetrahydrofolate biosynthetic process	BP
GO:0046677	response to antibiotic	BP
GO:0031427	response to methotrexate	BP
GO:0004146	dihydrofolate reductase activity	MF
GO:0042493	response to drug	BP
GO:0009165	nucleotide biosynthetic process	BP
GO:0006545	glycine biosynthetic process	BP
GO:0050661	NADP binding	MF
GO:0006730	one-carbon metabolic process	BP

Sequence

>gi|16128042|ref|NP_414590.1| dihydrofolate reductase [Escherichia coli str. K-12 substr. MG1655]
MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIILSSQPGTDD
RVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGDTHFPDYEPDDWESVFSEF
HDADAQNSHSYCFEILERR

Database Cross Reference

Ensembl Gene
UniGene
PDB	1DYI 1RA9 3QL3 1JOM 2INQ 1RX7 1RX5 1RX9 1RX2 3DRC 1DRE 4DFR 1DHJ 1RX6 1RX8 1RA2 3K74 1RB2 1RD7 1RB3 1RG7 1DHI 3DAU 1RX1 1RF7 1DDS 2ANQ 1DRB 7DFR 3OCH 1DRH 1RX3 1DYJ 1DYH 1TDR 1RA1 1DDR 1RC4 1JOL 2DRC 2ANO 1RA8 1RX4 3KFY 1RH3 1RE7 1DRA 1RA3 5DFR 6DFR 2D0K
RefSeq	NP_414590.1
Pfam	PF00186

PTID

dihydrofolate reductase

General Information (Source: NCBI Gene,UniProt)

General annotation

Gene Ontology

Sequence

Options for BLAST

Database:

Set subsequence:(optional):

Optional parameters:

Database Cross Reference