| Text mining Term | dihydrofolate reductase |
|---|---|
| UniProt ID | DYR_ECOLI |
| Name |
Dihydrofolate reductase |
| Gene Names |
folA
Synonyms:tmrA |
| Taxonomy | Escherichia coli K-12 |
| Function |
Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. |
|---|---|
| Subcellular location |
| GO:0031427 | response to methotrexate | BP |
| GO:0006730 | one-carbon metabolic process | BP |
| GO:0009165 | nucleotide biosynthetic process | BP |
| GO:0046677 | response to antibiotic | BP |
| GO:0042493 | response to drug | BP |
| GO:0050661 | NADP binding | MF |
| GO:0004146 | dihydrofolate reductase activity | MF |
| GO:0009257 | 10-formyltetrahydrofolate biosynthetic process | BP |
| GO:0006545 | glycine biosynthetic process | BP |
>gi|16128042|ref|NP_414590.1| dihydrofolate reductase [Escherichia coli str. K-12 substr. MG1655] MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIILSSQPGTDD RVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGDTHFPDYEPDDWESVFSEF HDADAQNSHSYCFEILERR |
| Ensembl Gene | |
|---|---|
| UniGene | |
| PDB |
1TDR 1RX8 1DRB 1RA9 1RG7 1RX2 1RX5 1RC4 1DDS 3DAU 1DYI 1JOM 1RX4 1RE7 1RB3 1RA2 1DYJ 5DFR 1DYH 3OCH 3DRC 6DFR 1RX7 2D0K 1RF7 1RA3 1DRE 1RA8 1RX9 2ANO 2INQ 2ANQ 7DFR 1DDR 1JOL 2DRC 1RH3 1RD7 1RB2 1DHI 1RX1 3KFY 3K74 1RA1 1DRH 1RX3 1DHJ 1RX6 3QL3 1DRA 4DFR |
| RefSeq |
NP_414590.1 |
| Pfam |
PF00186 |