dihydrofolate reductase

General Information (Source: NCBI Gene,UniProt)

Text mining Term dihydrofolate reductase
UniProt ID DYR_ECOLI
Name Dihydrofolate reductase
Gene Names folA
Synonyms:tmrA
Taxonomy Escherichia coli K-12

General annotation

Function Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.
Subcellular location

Gene Ontology

GO:0031427 response to methotrexate BP
GO:0009165 nucleotide biosynthetic process BP
GO:0006730 one-carbon metabolic process BP
GO:0046677 response to antibiotic BP
GO:0042493 response to drug BP
GO:0004146 dihydrofolate reductase activity MF
GO:0006545 glycine biosynthetic process BP
GO:0050661 NADP binding MF
GO:0009257 10-formyltetrahydrofolate biosynthetic process BP

Sequence

>gi|16128042|ref|NP_414590.1| dihydrofolate reductase [Escherichia coli str. K-12 substr. MG1655]
MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIILSSQPGTDD
RVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGDTHFPDYEPDDWESVFSEF
HDADAQNSHSYCFEILERR

Options for BLAST

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Database Cross Reference

Ensembl Gene
UniGene
PDB 1DHJ
2DRC
1RE7
1DYI
2ANQ
1RB3
3DAU
1RA3
1DRE
5DFR
1DDR
1RX1
1DRH
6DFR
1RA8
3DRC
3KFY
1RB2
1JOM
1RX9
1DDS
1RX6
3OCH
1RF7
1RA9
1DYJ
2ANO
2D0K
1RA2
1RG7
7DFR
1RX5
3K74
1RD7
2INQ
1RX4
1TDR
1RA1
1RX2
1DRA
1DYH
3QL3
1DHI
1RX7
1JOL
4DFR
1RC4
1DRB
1RX8
1RH3
1RX3
RefSeq NP_414590.1
Pfam PF00186