Text mining Term | dihydrofolate reductase |
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UniProt ID | DYR_ECOLI |
Name |
Dihydrofolate reductase |
Gene Names |
folA
Synonyms:tmrA |
Taxonomy | Escherichia coli K-12 |
Function |
Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. |
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Subcellular location |
GO:0031427 | response to methotrexate | BP |
GO:0009165 | nucleotide biosynthetic process | BP |
GO:0006730 | one-carbon metabolic process | BP |
GO:0046677 | response to antibiotic | BP |
GO:0042493 | response to drug | BP |
GO:0004146 | dihydrofolate reductase activity | MF |
GO:0006545 | glycine biosynthetic process | BP |
GO:0050661 | NADP binding | MF |
GO:0009257 | 10-formyltetrahydrofolate biosynthetic process | BP |
>gi|16128042|ref|NP_414590.1| dihydrofolate reductase [Escherichia coli str. K-12 substr. MG1655] MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIILSSQPGTDD RVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGDTHFPDYEPDDWESVFSEF HDADAQNSHSYCFEILERR |
Ensembl Gene | |
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UniGene | |
PDB |
1DHJ 2DRC 1RE7 1DYI 2ANQ 1RB3 3DAU 1RA3 1DRE 5DFR 1DDR 1RX1 1DRH 6DFR 1RA8 3DRC 3KFY 1RB2 1JOM 1RX9 1DDS 1RX6 3OCH 1RF7 1RA9 1DYJ 2ANO 2D0K 1RA2 1RG7 7DFR 1RX5 3K74 1RD7 2INQ 1RX4 1TDR 1RA1 1RX2 1DRA 1DYH 3QL3 1DHI 1RX7 1JOL 4DFR 1RC4 1DRB 1RX8 1RH3 1RX3 |
RefSeq |
NP_414590.1 |
Pfam |
PF00186 |