dihydrofolate reductase

General Information (Source: NCBI Gene,UniProt)

Text mining Term	dihydrofolate reductase
UniProt ID	DYR_ECOLI
Name	Dihydrofolate reductase
Gene Names	folA Synonyms:tmrA
Taxonomy	Escherichia coli K-12

General annotation

Function	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.
Subcellular location

Gene Ontology

GO:0009257	10-formyltetrahydrofolate biosynthetic process	BP
GO:0006545	glycine biosynthetic process	BP
GO:0004146	dihydrofolate reductase activity	MF
GO:0050661	NADP binding	MF
GO:0046677	response to antibiotic	BP
GO:0042493	response to drug	BP
GO:0009165	nucleotide biosynthetic process	BP
GO:0006730	one-carbon metabolic process	BP
GO:0031427	response to methotrexate	BP

Sequence

>gi|16128042|ref|NP_414590.1| dihydrofolate reductase [Escherichia coli str. K-12 substr. MG1655]
MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIILSSQPGTDD
RVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGDTHFPDYEPDDWESVFSEF
HDADAQNSHSYCFEILERR

Database Cross Reference

Ensembl Gene
UniGene
PDB	2ANO 5DFR 1RX8 1DYJ 2ANQ 3KFY 1RG7 1DDS 1RX7 3DRC 1RX9 1RA1 1JOM 1RX2 1DRB 2D0K 1RC4 4DFR 2INQ 7DFR 3DAU 1DYH 1RE7 1RD7 1DRA 6DFR 1DDR 1RX6 3K74 1DRE 1RH3 1TDR 1DHI 1DHJ 3QL3 2DRC 1RA9 1RF7 1RX3 1RX5 3OCH 1RB2 1RX1 1DRH 1RA3 1JOL 1DYI 1RA8 1RX4 1RB3 1RA2
RefSeq	NP_414590.1
Pfam	PF00186

PTID

dihydrofolate reductase

General Information (Source: NCBI Gene,UniProt)

General annotation

Gene Ontology

Sequence

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Database Cross Reference