| Text mining Term | dihydrofolate reductase |
|---|---|
| UniProt ID | DYR_ECOLI |
| Name |
Dihydrofolate reductase |
| Gene Names |
folA
Synonyms:tmrA |
| Taxonomy | Escherichia coli K-12 |
| Function |
Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. |
|---|---|
| Subcellular location |
| GO:0050661 | NADP binding | MF |
| GO:0004146 | dihydrofolate reductase activity | MF |
| GO:0009257 | 10-formyltetrahydrofolate biosynthetic process | BP |
| GO:0009165 | nucleotide biosynthetic process | BP |
| GO:0042493 | response to drug | BP |
| GO:0006545 | glycine biosynthetic process | BP |
| GO:0046677 | response to antibiotic | BP |
| GO:0031427 | response to methotrexate | BP |
| GO:0006730 | one-carbon metabolic process | BP |
>gi|16128042|ref|NP_414590.1| dihydrofolate reductase [Escherichia coli str. K-12 substr. MG1655] MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIILSSQPGTDD RVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGDTHFPDYEPDDWESVFSEF HDADAQNSHSYCFEILERR |
| Ensembl Gene | |
|---|---|
| UniGene | |
| PDB |
1DRB 1RF7 2D0K 1RC4 1RB2 1RX6 1RX8 1RA2 1RH3 1DHI 1DRE 1RX4 3DAU 1RA1 1RX3 5DFR 3K74 1DRA 3QL3 1RA9 1TDR 2ANO 1DYH 1DDS 4DFR 2DRC 1DHJ 1RX5 1JOM 1JOL 6DFR 1DDR 1DRH 1RA8 1RD7 7DFR 1DYJ 1RX7 1RX2 1RX1 2INQ 3OCH 2ANQ 1RG7 1RX9 1RE7 1RB3 3DRC 3KFY 1RA3 1DYI |
| RefSeq |
NP_414590.1 |
| Pfam |
PF00186 |