dihydrofolate reductase

General Information (Source: NCBI Gene,UniProt)

Text mining Term	dihydrofolate reductase
UniProt ID	DYR_ECOLI
Name	Dihydrofolate reductase
Gene Names	folA Synonyms:tmrA
Taxonomy	Escherichia coli K-12

General annotation

Function	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.
Subcellular location

Gene Ontology

GO:0006545	glycine biosynthetic process	BP
GO:0004146	dihydrofolate reductase activity	MF
GO:0009257	10-formyltetrahydrofolate biosynthetic process	BP
GO:0009165	nucleotide biosynthetic process	BP
GO:0031427	response to methotrexate	BP
GO:0006730	one-carbon metabolic process	BP
GO:0046677	response to antibiotic	BP
GO:0042493	response to drug	BP
GO:0050661	NADP binding	MF

Sequence

>gi|16128042|ref|NP_414590.1| dihydrofolate reductase [Escherichia coli str. K-12 substr. MG1655]
MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIILSSQPGTDD
RVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGDTHFPDYEPDDWESVFSEF
HDADAQNSHSYCFEILERR

Database Cross Reference

Ensembl Gene
UniGene
PDB	1DDR 1DRB 3DRC 1RX1 1RA9 1RX5 4DFR 1RX9 1RB3 1RA2 1RA8 1DHI 1RX2 1RE7 1DRE 1JOL 1RC4 1DYJ 1RX3 1RX4 3OCH 1DYI 7DFR 1RG7 2DRC 1RB2 3KFY 1DHJ 1RH3 1DDS 6DFR 1RD7 2ANO 1DRH 2INQ 1RF7 1RX6 1RA3 1RA1 1RX8 1DYH 1RX7 5DFR 3QL3 3K74 1TDR 3DAU 1DRA 2ANQ 2D0K 1JOM
RefSeq	NP_414590.1
Pfam	PF00186

PTID

dihydrofolate reductase

General Information (Source: NCBI Gene,UniProt)

General annotation

Gene Ontology

Sequence

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Database Cross Reference