| Name | transthyretins |
|---|---|
| Synonyms | ATTR; HsT2651; PALB; Prealbumin; TBPA; TTR; Transthyretin; Transthyretin precursor… |
| Name | ioxynil |
|---|---|
| CAS | 4-hydroxy-3,5-diiodobenzonitrile |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 3146151 | Ogilvie LM, Ramsden DB: Ioxynil and 3,5,3'- comparison of binding to human plasma proteins. Toxicol Lett. 1988 Dec;44(3):281-7. The Ka calculated for the TBPA-ioxynil complex was 2.6 x 10 (6) l.mol-1. |
168(2,2,3,3) | Details |
| 18243807 | Eguchi R, Ishihara A, Yamauchi K: Interaction of diethylstilbestrol and ioxynil with transthyretin in chicken serum. Comp Biochem Physiol C Toxicol Pharmacol. 2008 Apr;147(3):345-50. Epub 2008 Jan 12. |
112(1,2,2,2) | Details |
| 19375178 | Morgado I, Campinho MA, Costa R, Jacinto R, Power DM: Disruption of the thyroid system by diethylstilbestrol and ioxynil in the sea bream (Sparus aurata). Aquat Toxicol. 2009 May 17;92(4):271-80. Epub 2009 Mar 6. Ioxynil (IOX) and diethylstilbestrol (DES) are potential EDCs with strong affinity in vitro for sea bream transthyretin (TTR), a TH distributor protein (THDP). |
81(1,1,1,1) | Details |
| 12553426 | Yamauchi K, Eguchi R, Shimada N, Ishihara A: The effects of endocrine-disrupting chemicals on thyroid hormone binding to Xenopus laevis transthyretin and thyroid hormone receptor. Clin Chem Lab Med. 2002 Dec;40(12):1250-6. The xTTR's relative affinities for diethylstilbestrol, pentachlorophenol and ioxynil were 10 (-1)- to 10 (-2)-fold less than that for T3. |
2(0,0,0,2) | Details |
| 12581883 | Ishihara A, Sawatsubashi S, Yamauchi K: Endocrine disrupting chemicals: interference of thyroid hormone binding to transthyretins and to thyroid hormone receptors. Mol Cell Endocrinol. 2003 Jan 31;199(1-2):105-17. Scatchard analysis revealed DES, pentachlorophenol and ioxynil as competitive inhibitors of [125I] T (3) binding to cTTR and bTTR. |
2(0,0,0,2) | Details |
| 13129501 | Ishihara A, Nishiyama N, Sugiyama S, Yamauchi K: The effect of endocrine disrupting chemicals on thyroid hormone binding to Japanese quail transthyretin and thyroid hormone receptor. Gen Comp Endocrinol. 2003 Oct 15;134(1):36-43. Diethylstilbestrol, ioxynil (IC50 =1.1+/-0.5 nM) and pentachlorophenol (IC50 = 6.3+/-3.8 nM) displaced [125I] T3 from qTTR more effectively than unlabeled T3 (IC50 = 9.7+/-0.9 nM) did. |
2(0,0,0,2) | Details |
| 17553549 | Morgado I, Hamers T, Van der Ven L, Power DM: Disruption of thyroid hormone binding to sea bream recombinant transthyretin by ioxinyl and polybrominated diphenyl ethers. Chemosphere. 2007 Aug;69(1):155-63. Epub 2007 Jun 5. |
2(0,0,0,2) | Details |