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methoprene

Identification (Source:EPA,EU)

ID	1427
Name	methoprene
CAS	40596-69-8
IUPAC
Inchi	InChI=1S/C19H34O3/c1-15(2)22-18(20)14-17(4)11-8-10-16(3)12-9-13-19(5,6)21-7/h8,11,14-16H,9-10,12-13H2,1-7H3/b11-8+,17-14+
CIPAC	414
EPA Code	105401
Formula	C19H34O3
SMILES	O=C(OC(C)C)\C=C(\C=C\CC(CCCC(OC)(C)C)C)C
Status	Not Approved

Classification

Mode of Action	Contact and stomach action, acts by mimicing the action of the juvenile hormone keeping the insect in an immature state
Pesticide Type	Insecticide
Chemical Group	Juvenile hormone mimic (terpene)
Classification	juvenile hormone mimics

Properties (Source:PubChem)

Molecular Weight	310.47
Physical State	Yellow to amber coloured liquid
AlogP	5.059
H-Bond Donor	0
H-Bond Acceptor	3
Surface Area	366.4
Polar Surface Area	35.53

Structure

Ecotoxicology (Source:PPDB,IPM)

Species	Method	Study Time	Dose Type	Value
Algae	Acute	72 hour	EC50, growth	1.33 mg l-1
Aquatic crustaceans	Acute	96 hour	LC50	0.106 mg l-1
Aquatic invertebrates	Chronic	21 day	NOEC	0.051 mg l-1
Aquatic invertebrates	Acute	48 hour	EC50	0.089 mg l-1
Birds	Acute		LD50	2250 mg kg-1
Fish	Acute	96 hour	LC50	0.76 mg l-1
Honeybees	Acute	48 hour	LD50	1000 μg bee-1
Mammals	Acute oral		LD50	> 34600 mg kg-1
Mammals	Short term dietary		NOEL	5000 ppm diet
	Bio-concentration factor		BCF	457
	Bio-concentration factor		CT50	Not available days

Related targets

Target Name	RScore (About this table)
retinoid X receptor (protein family or complex)	445(5,6,6,15)	Details
RXRalpha	86(1,1,1,6)	Details
bcl 2	84(1,1,1,4)	Details
caspase 1	83(1,1,1,3)	Details
RXRbeta	82(1,1,1,2)	Details
ftz f1	81(1,1,1,1)	Details
NA K ATPase	43(0,1,3,3)	Details
caspase 3	37(0,1,1,7)	Details
Cytochrome c oxidase (protein family or complex)	36(0,1,1,6)	Details
ATPase	31(0,1,1,1)	Details
retinol dehydrogenase	31(0,1,1,1)	Details
pig a	31(0,1,1,1)	Details
muscles	32(0,0,2,22)	Details
chitinase	16(0,0,1,11)	Details
brown adipose tissue uncoupling protein	13(0,0,1,8)	Details
C18	9(0,0,1,4)	Details
lipase	9(0,0,1,4)	Details
Sonic hedgehog	8(0,0,1,3)	Details
test 1	7(0,0,1,2)	Details
Met protein	7(0,0,1,2)	Details
epoxide hydrolase	7(0,0,0,7)	Details
GAL4	7(0,0,1,2)	Details
per 3	6(0,0,1,1)	Details
ha 5	6(0,0,1,1)	Details
lysosomal phospholipase A2	6(0,0,0,6)	Details

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