Publications
Shaoying Tan†, Deheng Sun†, Jiankun Lyu†, Xiao Sun, Fangshu Wu, Qiang Li, Yiqi Yang, Jianxu Liu, Xin Wang, Zhuo Chen*, Honglin Li*, Xuhong Qian, Yufang Xu*. Antiproliferative and apoptosis-inducing activities of novel naphthalimide–cyclam conjugates through dual topoisomerase (topo) I/II inhibition. Bioorgan. Med. Chem. 2015, 23(17), 5672-5680, doi:10.1016/j.bmc.2015.07.011
Deheng Sun‡, Yu Yang‡, Jiankun Lyu‡, Wei Zhou, Wenlin Song, Zhenjiang Zhao, Zhuo Chen*, Yufang Xu*, and Honglin Li*. Discovery and rational design of pteridin-7(8H)-one-based inhibitors targeting FMS-like tyrosine kinase 3 (FLT3) and its mutants. J. Med. Chem. 2016, 59(13): 6187-6200, doi:10.1021/acs.jmedchem.6b00374
Yongjia Hao†, Jiankun Lyu†, Rong Qu†, Deheng Sun, Zhenjiang Zhao, Zhuo Chen, Jian Ding, Hua Xie*, Yufang Xu*, Honglin Li*. Structure-Guided Design of C4-alkyl-1,4-dihydro-2H-pyrimido[4,5-d][1,3]oxazin-2-ones as Potent and Mutant-Selective Epidermal Growth Factor Receptor (EGFR) L858R/T790M Inhibitors. Sci. Rep., 2017, 7 : 3830.
Yongjia Hao†, Jiankun Lyu†, Rong Qu†, Yi Tong, Deheng Sun, Fang Feng, Linjiang Tong, Tingyuan Yang, Zhenjiang Zhao, Lili Zhu, Jian Ding, Yufang Xu*, Hua Xie*, Honglin Li*. Design, Synthesis, and Biological Evaluation of Pyrimido[4,5-d]pyrimidine-2,4(1H, 3H)-diones as Potent and Selective Epidermal Growth Factor Receptor (EGFR) Inhibitors against L858R/T790M Resistance Mutation. J. Med. Chem., 2018, 61 (13), 5609-5622.
Qiao Li†, Lina Quan†, Jiankun Lyu, Zenghui He, Xia Wang, Jiajia Meng, Zhenjiang Zhao, Lili Zhu*, Xiaofeng Liu*, Honglin Li*. Discovery of peptide inhibitors targeting human programmed death 1 (PD-1) receptor. Oncotarget, 2016, 7 : 64967-64976.
Yi Tong†, Qian Jiao†, Yuanru Liu, Jiankun Lyu, and Rui Wang* and Lili Zhu*. Maprotiline Prevents Monocrotaline-Induced Pulmonary Arterial Hypertension in Rats. Front. Pharmacol., 2018, 9 : 1032.
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