Multi-agent AI for therapeutic target discovery

A virtual target review board,built from AI experts.

TargetMind convenes independent domain-expert agents to investigate, challenge and reconcile biomedical evidence, and ranks therapeutic targets only once they reach a structured consensus.

Explore capabilities

A virtual roundtable: a chief scientist and four domain-expert agents deliberate over protein structure, single-cell, genetic and membrane-target evidence

Step inside the TargetMind

Tools and databases

Every expert works from the same evidence infrastructure

A registry of 694 biomedical tools spanning six domains gives each agent direct access to primary data sources rather than recalled knowledge.

Biomedical tools registry across six domains: general, disease, target, drug, pathway and omics tools

biomedical tools: 694
evidence domains: 6
data sources: 27

Gene and protein identity, structures, tractability, safety, homology and druggability prediction.

Where the tools come from

Open Targets34
UniProt26
ChEMBL20
RCSB PDB20
Ensembl17
+2 more4

Highlights

get_target_tractability_by_ensemblID
Retrieve tractability assessments, including modality and values, for a specific target Ensembl ID
predict_single_gene_druggability
Predicts the druggability of a single gene using a machine learning model
pdb_get_structure
Retrieve detailed structure information for a PDB entry
get_target_safety_profile_by_ensemblID
Retrieve known target safety liabilities for a specific target Ensembl ID

Explore capability hub →

Browse all 694 tools, the software environment and our datasets.

Counts come from the current tool registry; the per-domain values in the paper figure are approximate.

get_chembl_id_lookupget_document_by_idget_source_idsearch_documentget_info_compara_methodsget_info_genomesget_info_softwareget_publications_by_disease_efoIdopentargets_search_entityvisualize_evidence_chainclinvar_query_sequence_variantsget_studiesget_joint_associated_diseases_by_HPO_ID_listget_associated_targets_by_disease_efoIdget_disease_description_by_nameget_disease_therapeutic_areas_by_efoIdopentargets_get_disease_infochembl_get_target_activitiesget_protein_classification_idget_target_idsget_cafe_genetree_member_idget_lookup_idpost_lookup_idget_chemical_probes_by_target_nameget_target_enabling_packages_by_ensemblIDget_target_id_description_by_nameget_target_tractability_by_ensemblIDopentargets_get_target_safetypdb_get_drugbank_annotationspdb_get_polymer_entitypdb_get_structureget_proteome_by_idget_uniref_light_cluster_by_idstream_proteomesuniprot_get_protein_infoget_activity_supplementary_data_by_activityget_assay_class_by_idget_biotherapeutic_by_idsget_compound_structural_alert_by_idsget_drug_warningget_metabolism_idget_molecule_idsdrugbank_get_drug_targetsget_associated_drugs_by_disease_efoIdget_drug_description_by_chemblIdget_drug_trade_names_by_chemblIdget_similar_entities_by_drug_nameget_compound_by_cidget_compounds_by_smilesget_isomeric_smilesget_chembl_id_lookupget_document_by_idget_source_idsearch_documentget_info_compara_methodsget_info_genomesget_info_softwareget_publications_by_disease_efoIdopentargets_search_entityvisualize_evidence_chainclinvar_query_sequence_variantsget_studiesget_joint_associated_diseases_by_HPO_ID_listget_associated_targets_by_disease_efoIdget_disease_description_by_nameget_disease_therapeutic_areas_by_efoIdopentargets_get_disease_infochembl_get_target_activitiesget_protein_classification_idget_target_idsget_cafe_genetree_member_idget_lookup_idpost_lookup_idget_chemical_probes_by_target_nameget_target_enabling_packages_by_ensemblIDget_target_id_description_by_nameget_target_tractability_by_ensemblIDopentargets_get_target_safetypdb_get_drugbank_annotationspdb_get_polymer_entitypdb_get_structureget_proteome_by_idget_uniref_light_cluster_by_idstream_proteomesuniprot_get_protein_infoget_activity_supplementary_data_by_activityget_assay_class_by_idget_biotherapeutic_by_idsget_compound_structural_alert_by_idsget_drug_warningget_metabolism_idget_molecule_idsdrugbank_get_drug_targetsget_associated_drugs_by_disease_efoIdget_drug_description_by_chemblIdget_drug_trade_names_by_chemblIdget_similar_entities_by_drug_nameget_compound_by_cidget_compounds_by_smilesget_isomeric_smiles

get_substance_by_sidget_xlogpsearch_pubchem_by_smilesget_alarms_by_drug_nameget_child_safety_info_by_drug_nameget_dependence_info_by_drug_nameget_drug_interactions_by_drug_nameget_drug_name_by_dosage_infoget_drug_name_by_pharmacodynamicsget_drug_name_by_storage_and_handling_infoget_drug_names_by_animal_pharmacology_infoget_drug_names_by_clinical_studiesget_drug_names_by_effective_timeget_drug_names_by_info_on_consulting_doctor_pharmacist_for_drug_interactionsget_drug_names_by_medication_guideget_drug_names_by_pregnancy_effects_infoget_drug_names_by_teratogenic_effectsget_health_claims_by_drug_nameget_information_for_owners_or_caregivers_by_drug_nameget_medication_guide_info_by_drug_nameget_pediatric_use_info_by_drug_nameget_pregnancy_or_breastfeeding_info_by_drug_nameget_route_info_by_drug_nameget_teratogenic_effects_by_drug_nameretrieve_drug_names_by_patient_medication_infoget_ontology_descendantskegg_findget_target_gene_ontology_by_ensemblIDphipster_vpname2vpidget_functional_enrichmentmirdb_get_geneset_by_mirnameget_tissueget_ga4gh_beacon_queryget_ga4gh_variantannotationsetsget_mapget_taxonomy_classificationget_variation_pmidpost_ga4gh_features_searchpost_ga4gh_variantsets_searchpost_vep_regionget_gene_by_accession_dataset_reportget_gene_by_taxon_product_reportget_gene_orthologsget_genome_dataset_report_by_assembly_nameget_genome_linksget_sequence_assembliesget_taxonomy_related_idsget_virus_dataset_reportget_cytobandlist_tracksget_substance_by_sidget_xlogpsearch_pubchem_by_smilesget_alarms_by_drug_nameget_child_safety_info_by_drug_nameget_dependence_info_by_drug_nameget_drug_interactions_by_drug_nameget_drug_name_by_dosage_infoget_drug_name_by_pharmacodynamicsget_drug_name_by_storage_and_handling_infoget_drug_names_by_animal_pharmacology_infoget_drug_names_by_clinical_studiesget_drug_names_by_effective_timeget_drug_names_by_info_on_consulting_doctor_pharmacist_for_drug_interactionsget_drug_names_by_medication_guideget_drug_names_by_pregnancy_effects_infoget_drug_names_by_teratogenic_effectsget_health_claims_by_drug_nameget_information_for_owners_or_caregivers_by_drug_nameget_medication_guide_info_by_drug_nameget_pediatric_use_info_by_drug_nameget_pregnancy_or_breastfeeding_info_by_drug_nameget_route_info_by_drug_nameget_teratogenic_effects_by_drug_nameretrieve_drug_names_by_patient_medication_infoget_ontology_descendantskegg_findget_target_gene_ontology_by_ensemblIDphipster_vpname2vpidget_functional_enrichmentmirdb_get_geneset_by_mirnameget_tissueget_ga4gh_beacon_queryget_ga4gh_variantannotationsetsget_mapget_taxonomy_classificationget_variation_pmidpost_ga4gh_features_searchpost_ga4gh_variantsets_searchpost_vep_regionget_gene_by_accession_dataset_reportget_gene_by_taxon_product_reportget_gene_orthologsget_genome_dataset_report_by_assembly_nameget_genome_linksget_sequence_assembliesget_taxonomy_related_idsget_virus_dataset_reportget_cytobandlist_tracks

The platform

A working research platform, not just a paper

Start from a disease, let the review board plan and execute the investigation, and inspect every intermediate result — tables, code, reports and 3D structures — in one workspace.

TargetMind

Disease grounding

Search any disease and anchor the workspace to its OpenTargets ontology IDs (EFO / MONDO).

Live research plan

The agents publish a task plan and update its progress as they work.

Every result is a file

Tables, figures, code and reports land in the results panel — preview, filter and download.

Built-in 3D structures

PDB, SDF and other structure files open directly in an interactive Mol* viewer.

Benchmark

Stronger target reasoning, deeper into unexplored biology

Therapeutic target reasoning

Significantly outperforms state-of-the-art biomedical agents and general-purpose models across standardized therapeutic target reasoning tasks.

Novel target discovery

Navigates beyond well-studied genetic networks to prioritize highly underexplored targets with robust disease-linked support.

Target space map showing TargetMind's picks in the underexplored region versus baselines in the well-studied region, and bar charts comparing TargetMind with baselines on TRQA benchmarks — Top: TargetMind's prioritized targets fall in the underexplored region of target space, while baselines concentrate in the well-studied region. Bottom: TRQA-lit choice questions (accuracy), TRQA-lit short-answer and TRQA-db (average recall), compared with OriGene, GPT-4o-Search, o3-mini, DeepSeek-R1, DeepSeek-V3, Claude-3.7-Sonnet and Gemini-2.5-Pro.

Experimental validation

From computational reasoning to the bench

TargetMind's top-ranked candidates were taken into experimental investigation across three disease models — renal fibrosis, polycystic kidney disease and hypertrophic cardiomyopathy.

Experimental validation across three disease models: renal fibrosis, polycystic kidney disease and hypertrophic cardiomyopathy, each ending in a validated therapeutic target

Bring a review board to your next target.

byndclf@163.com