glucose 6 phosphatase

General Information (Source: NCBI Gene,UniProt)

Text mining Term glucose 6 phosphatase
UniProt ID G6PC_RAT
Name Glucose-6-phosphatase
G-6-Pase
G6Pase
Gene Names G6pc
Synonyms:G6pt
Taxonomy Rattus norvegicus

General annotation

Function Hydrolyzes glucose-6-phosphate to glucose in the endoplasmic reticulum. Forms with the glucose-6-phosphate transporter (SLC37A4/G6PT) the complex responsible for glucose production through glycogenolysis and gluconeogenesis. Hence, it is the key enzyme in homeostatic regulation of blood glucose levels (By similarity).
Subcellular location Endoplasmic reticulum membrane; Multi-pass membrane protein.

Gene Ontology

GO:0055088 lipid homeostasis BP
GO:0005792 microsome CC
GO:0005789 endoplasmic reticulum membrane CC
GO:0006094 gluconeogenesis BP
GO:0004346 glucose-6-phosphatase activity MF
GO:0051156 glucose 6-phosphate metabolic process BP
GO:0046838 phosphorylated carbohydrate dephosphorylation BP
GO:0042593 glucose homeostasis BP
GO:0016021 integral to membrane CC
GO:0032094 response to food BP

Sequence

>gi|145207998|ref|NP_037230.2| glucose-6-phosphatase [Rattus norvegicus]
MEERMNVLHDFGIQSTRYLQVNYEDSQDWFVLVSVIADLRNAFYVLFPIWFHIQETVGINLLWVAVVGDW
FNLVFKWILFGQRPYWWVLDTDYYSNSSVPLIKQFPVTCETGPGSPSGHAMGTAGVYYVMVTSTLAIFRG
KKKSTYGFRCLNVVLWLGYWAVQLNVCLSRIYLAAHFPHQVVAGVLSGIAVAETFSHIRGIYNASLQRYC
LITFFLFGFALGFYLLLKGLGVDLLWTLEKAKRWCERPEWVHLDTTPFASLFKNLGTLLGLGLALNSSMY
RKSCKGELRKSLPFRLACIVASLGLLHLFDSLKPPSQIESIFYILSFCKSATVPFASVSLIPYCLARLLG
QTHKKSL

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Database Cross Reference

Ensembl Gene
UniGene Rn.10992
PDB
RefSeq NP_037230.2
Pfam PF01569