osteonectin

General Information (Source: NCBI Gene,UniProt)

Text mining Term osteonectin
UniProt ID SPRC_RAT
Name Secreted protein acidic and rich in cysteine
BM-40
ON
SPARC
Osteonectin
Basement-membrane protein 40
Gene Names Sparc
Taxonomy Rattus norvegicus

General annotation

Function Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium binding sites; an acidic domain that binds 5 to 8 Ca(2+) with a low affinity and an EF-hand loop that binds a Ca(2+) ion with a high affinity.
Subcellular location Secreted, extracellular space, extracellular matrix, basement membrane. Note=In or around the basement membrane (By similarity).

Gene Ontology

GO:0005509 calcium ion binding MF
GO:0009629 response to gravity BP
GO:0043434 response to peptide hormone stimulus BP
GO:0007507 heart development BP
GO:0007165 signal transduction BP
GO:0051591 response to cAMP BP
GO:0034097 response to cytokine stimulus BP
GO:0001503 ossification BP
GO:0045471 response to ethanol BP
GO:0051592 response to calcium ion BP
GO:0046686 response to cadmium ion BP
GO:0042060 wound healing BP
GO:0005604 basement membrane CC
GO:0005737 cytoplasm CC
GO:0005634 nucleus CC
GO:0048839 inner ear development BP
GO:0032496 response to lipopolysaccharide BP
GO:0031988 membrane-bounded vesicle CC
GO:0030324 lung development BP
GO:0051384 response to glucocorticoid stimulus BP
GO:0010288 response to lead ion BP
GO:0033591 response to L-ascorbic acid BP
GO:0005615 extracellular space CC

Sequence

>gi|6981574|ref|NP_036788.1| SPARC precursor [Rattus norvegicus]
MRAWIFFLLCLAGRALAAPQTEAAEEMVAEETVVEETGLPVGANPVQVEMGEFEEGAEETVEEVVAENPC
QNHHCKHGKVCELDESNTPMCVCQDPTSCPAPIGEFEKVCSNDNKTFDSSCHFFATKCTLEGTKKGHKLH
LDYIGPCKYIAPCLDSELTEFPLRMRDWLKNVLVTLYERDEGNNLLTEKQKLRVKKIHENEKRLEAGDHP
VELLARDFEKNYNMYIFPVHWQFGQLDQHPIDGYLSHTELAPLRAPLIPMEHCTTRFFETCDLDNDKYIA
LEEWAGCFGIKEQDINKDLVI

Options for BLAST

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Database Cross Reference

Ensembl Gene ENSRNOT00000017486
UniGene Rn.98989
PDB
RefSeq NP_036788.1
Pfam PF00050
PF09289
PF10591