vanilloid receptor 1

General Information (Source: NCBI Gene,UniProt)

Text mining Term vanilloid receptor 1
UniProt ID TRPV1_MOUSE
Name Vanilloid receptor 1
Osm-9-like TRP channel 1
OTRPC1
Transient receptor potential cation channel subfamily V member 1
TrpV1
Gene Names Trpv1
Taxonomy Mus musculus

General annotation

Function Receptor-activated non-selective calcium permeant cation channel involved in detection of noxious chemical and thermal stimuli. Seems to mediate proton influx and may be involved in intracellular acidosis in nociceptive neurons. May be involved in mediation of inflammatory pain and hyperalgesia. Sensitized by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases, which involves PKC isozymes and PCL (By similarity).
Subcellular location Cell membrane; Multi-pass membrane protein (By similarity).

Gene Ontology

GO:0005516 calmodulin binding MF
GO:0050968 detection of chemical stimulus involved in sensory perception of pain BP
GO:0060083 smooth muscle contraction involved in micturition BP
GO:0016021 integral to membrane CC
GO:0042637 catagen BP
GO:0002790 peptide secretion BP
GO:0005886 plasma membrane CC
GO:0005262 calcium channel activity MF
GO:0005524 ATP binding MF
GO:0009408 response to heat BP
GO:0001660 fever generation BP
GO:0009268 response to pH BP
GO:0050954 sensory perception of mechanical stimulus BP
GO:0048266 behavioral response to pain BP
GO:0043005 neuron projection CC
GO:0002024 diet induced thermogenesis BP
GO:0006629 lipid metabolic process BP

Sequence

>gi|47825364|ref|NP_001001445.1| transient receptor potential cation channel subfamily V member 1 [Mus musculus]
MEKWASLDSDESEPPAQENSCPDPPDRDPNSKPPPAKPHIFATRSRTRLFGKGDSEEASPMDCPYEEGGL
ASCPIITVSSVVTLQRSVDGPTCLRQTSQDSVSTGVETPPRLYDRRSIFDAVAQSNCQELESLLSFLQKS
KKRLTDSEFKDPETGKTCLLKAMLNLHNGQNDTIALLLDIARKTDSLKQFVNASYTDSYYKGQTALHIAI
ERRNMALVTLLVENGADVQAAANGDFFKKTKGRPGFYFGELPLSLAACTNQLAIVKFLLQNSWQPADISA
RDSVGNTVLHALVEVADNTADNTKFVTNMYNEILILGAKLHPTLKLEELTNKKGLTPLALAASSGKIGVL
AYILQREIHEPECRHLSRKFTEWAYGPVHSSLYDLSCIDTCEKNSVLEVIAYSSSETPNRHDMLLVEPLN
RLLQDKWDRFVKRIFYFNFFVYCLYMIIFTTAAYYRPVEGLPPYKLNNTVGDYFRVTGEILSVSGGVYFF
FRGIQYFLQRRPSLKSLFVDSYSEILFFVQSLFMLVSVVLYFSHRKEYVASMVFSLAMGWTNMLYYTRGF
QQMGIYAVMIEKMILRDLCRFMFVYLVFLFGFSTAVVTLIEDGKNNSLPVESPPHKCRGSACRPGNSYNS
LYSTCLELFKFTIGMGDLEFTENYDFKAVFIILLLAYVILTYILLLNMLIALMGETVNKIAQESKNIWKL
QRAITILDTEKSFLKCMRKAFRSGKLLQVGFTPDGKDDFRWCFRVDEVNWTTWNTNVGIINEDPGNCEGV
KRTLSFSLRSGRVSGRNWKNFALVPLLRDASTRDRHSTQPEEVQLKHYTGSLKPEDAEVFKDSMAPGEK

Options for BLAST

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Database Cross Reference

Ensembl Gene ENSMUST00000138853
ENSMUST00000108470
ENSMUST00000102526
ENSMUST00000006106
UniGene Mm.447485
PDB
RefSeq NP_001001445.1
Pfam PF00023
PF00520