Text mining Term | gephyrin |
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UniProt ID | GEPH_RAT |
Name |
Domain E Molybdopterin molybdenumtransferase MPT Mo-transferase MPT adenylyltransferase Molybdopterin adenylyltransferase Domain G Putative glycine receptor-tubulin linker protein Gephyrin |
Gene Names |
Gphn
Synonyms:Gph |
Taxonomy | Rattus norvegicus |
Function |
Microtubule-associated protein involved in membrane protein-cytoskeleton interactions. It is thought to anchor the inhibitory glycine receptor (GLYR) to subsynaptic microtubules (By similarity). Catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step, molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released. |
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Subcellular location |
Cell junction, synapse. Cell junction, synapse, postsynaptic cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Note=Cytoplasmic face of glycinergic postsynaptic membranes. |
GO:0005524 | ATP binding | MF |
GO:0045211 | postsynaptic membrane | CC |
GO:0030674 | protein binding, bridging | MF |
GO:0046872 | metal ion binding | MF |
GO:0042803 | protein homodimerization activity | MF |
GO:0030054 | cell junction | CC |
GO:0005737 | cytoplasm | CC |
GO:0005102 | receptor binding | MF |
GO:0032947 | protein complex scaffold | MF |
GO:0051260 | protein homooligomerization | BP |
GO:0006777 | Mo-molybdopterin cofactor biosynthetic process | BP |
GO:0015631 | tubulin binding | MF |
GO:0006605 | protein targeting | BP |
GO:0060077 | inhibitory synapse | CC |
GO:0005856 | cytoskeleton | CC |
GO:0005886 | plasma membrane | CC |
GO:0007416 | synapse assembly | BP |
GO:0016740 | transferase activity | MF |
>gi|88853561|ref|NP_074056.2| gephyrin [Rattus norvegicus] MATEGMILTNHDHQIRVGVLTVSDSCFRNLAEDRSGINLKDLVQDPSLLGGTISAYKIVPDEIEEIKETL IDWCDEKELNLILTTGGTGFAPRDVTPEATKEVIEREAPGMALAMLMGSLNVTPLGMLSRPVCGIRGKTL IINLPGSKKGSQECFQFILPALPHAIDLLRDAIVKVKEVHDELEDLPSPPPPLSPPPTTSPHKQTEDKGV QCEEEEEEKKDSGVASTEDSSSSHITAAALAAKIPDSIISRGVQVLPRDTASLSTTPSESPRAQATSRLS TASCPTPKVQSRCSSKENILRASHSAVDITKVARRHRMSPFPLTSMDKAFITVLEMTPVLGTEIINYRDG MGRVLAQDVYAKDNLPPFPASVKDGYAVRAADGPGDRFIIGESQAGEQPTQTVMPGQVMRVTTGAPIPCG ADAVVQVEDTELIRESDDGTEELEVRILVQARPGQDIRPIGHDIKRGECVLAKGTHMGPSEIGLLATVGV TEVEVNKFPVVAVMSTGNELLNPEDDLLPGKIRDSNRSTLLATIQEHGYPTINLGIVGDNPDDLLNALNE GISRADVIITSGGVSMGEKDYLKQVLDIDLHAQIHFGRVFMKPGLPTTFATLDIDGVRKIIFALPGNPVS AVVTCNLFVVPALRKMQGILDPRPTIIKARLSCDVKLDPRPEYHRCILTWHHQEPLPWAQSTGNQMSSRL MSMRSANGLLMLPPKTEQYVELHKGEVVDVMVIGRL |
Ensembl Gene | |
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UniGene |
Rn.11032 |
PDB |
1T3E 2FTS 1IHC 2FU3 |
RefSeq |
NP_074056.2 |
Pfam |
PF03453 PF00994 PF03454 |