gephyrin

General Information (Source: NCBI Gene,UniProt)

Text mining Term gephyrin
UniProt ID GEPH_RAT
Name Domain E
Molybdopterin adenylyltransferase
Gephyrin
Putative glycine receptor-tubulin linker protein
Domain G
MPT Mo-transferase
Molybdopterin molybdenumtransferase
MPT adenylyltransferase
Gene Names Gphn
Synonyms:Gph
Taxonomy Rattus norvegicus

General annotation

Function Microtubule-associated protein involved in membrane protein-cytoskeleton interactions. It is thought to anchor the inhibitory glycine receptor (GLYR) to subsynaptic microtubules (By similarity). Catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step, molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released.
Subcellular location Cell junction, synapse. Cell junction, synapse, postsynaptic cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Note=Cytoplasmic face of glycinergic postsynaptic membranes.

Gene Ontology

GO:0042803 protein homodimerization activity MF
GO:0005886 plasma membrane CC
GO:0030054 cell junction CC
GO:0051260 protein homooligomerization BP
GO:0005102 receptor binding MF
GO:0007416 synapse assembly BP
GO:0005856 cytoskeleton CC
GO:0045211 postsynaptic membrane CC
GO:0060077 inhibitory synapse CC
GO:0006605 protein targeting BP
GO:0005524 ATP binding MF
GO:0015631 tubulin binding MF
GO:0005737 cytoplasm CC
GO:0006777 Mo-molybdopterin cofactor biosynthetic process BP
GO:0016740 transferase activity MF
GO:0046872 metal ion binding MF
GO:0032947 protein complex scaffold MF
GO:0030674 protein binding, bridging MF

Sequence

>gi|88853561|ref|NP_074056.2| gephyrin [Rattus norvegicus]
MATEGMILTNHDHQIRVGVLTVSDSCFRNLAEDRSGINLKDLVQDPSLLGGTISAYKIVPDEIEEIKETL
IDWCDEKELNLILTTGGTGFAPRDVTPEATKEVIEREAPGMALAMLMGSLNVTPLGMLSRPVCGIRGKTL
IINLPGSKKGSQECFQFILPALPHAIDLLRDAIVKVKEVHDELEDLPSPPPPLSPPPTTSPHKQTEDKGV
QCEEEEEEKKDSGVASTEDSSSSHITAAALAAKIPDSIISRGVQVLPRDTASLSTTPSESPRAQATSRLS
TASCPTPKVQSRCSSKENILRASHSAVDITKVARRHRMSPFPLTSMDKAFITVLEMTPVLGTEIINYRDG
MGRVLAQDVYAKDNLPPFPASVKDGYAVRAADGPGDRFIIGESQAGEQPTQTVMPGQVMRVTTGAPIPCG
ADAVVQVEDTELIRESDDGTEELEVRILVQARPGQDIRPIGHDIKRGECVLAKGTHMGPSEIGLLATVGV
TEVEVNKFPVVAVMSTGNELLNPEDDLLPGKIRDSNRSTLLATIQEHGYPTINLGIVGDNPDDLLNALNE
GISRADVIITSGGVSMGEKDYLKQVLDIDLHAQIHFGRVFMKPGLPTTFATLDIDGVRKIIFALPGNPVS
AVVTCNLFVVPALRKMQGILDPRPTIIKARLSCDVKLDPRPEYHRCILTWHHQEPLPWAQSTGNQMSSRL
MSMRSANGLLMLPPKTEQYVELHKGEVVDVMVIGRL

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Database Cross Reference

Ensembl Gene
UniGene Rn.11032
PDB 2FTS
1IHC
1T3E
2FU3
RefSeq NP_074056.2
Pfam PF00994
PF03453
PF03454