| Text mining Term | progesterone receptor |
|---|---|
| UniProt ID | PRGR_RAT |
| Name |
PR Progesterone receptor Nuclear receptor subfamily 3 group C member 3 |
| Gene Names |
Pgr
Synonyms:Nr3c3 |
| Taxonomy | Rattus norvegicus |
| Function |
The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Progesterone receptor isoform is involved in activation of c-SRC/MAPK signaling on hormone stimulation (By similarity). |
|---|---|
| Subcellular location |
Nucleus. Cytoplasm. Note=Nucleoplasmic shuttling is both homone- and cell cycle-dependent. On hormone stimulation, retained in the cytoplasm in the G(1) and G(2)/M phases (By similarity). |
| GO:0005634 | nucleus | CC |
| GO:0042562 | hormone binding | MF |
| GO:0003700 | sequence-specific DNA binding transcription factor activity | MF |
| GO:0043565 | sequence-specific DNA binding | MF |
| GO:0045893 | positive regulation of transcription, DNA-dependent | BP |
| GO:0045892 | negative regulation of transcription, DNA-dependent | BP |
| GO:0071372 | cellular response to follicle-stimulating hormone stimulus | BP |
| GO:0005496 | steroid binding | MF |
| GO:0005829 | cytosol | CC |
| GO:0001553 | luteinization | BP |
| GO:0043005 | neuron projection | CC |
| GO:0003707 | steroid hormone receptor activity | MF |
| GO:0006351 | transcription, DNA-dependent | BP |
| GO:0016101 | diterpenoid metabolic process | BP |
| GO:0008270 | zinc ion binding | MF |
| GO:0071373 | cellular response to luteinizing hormone stimulus | BP |
>gi|12408292|ref|NP_074038.1| progesterone receptor [Rattus norvegicus] MTELQAKDPRTLHTSGAAPSPTHVGSPLLARLDPDPFQGSQHSDASSVVSPIPISLDRLLFSRSCQAQEL PDEKTQNQQSLSDVEGAFSGVEASRRRSRNPRAPEKDSRLLDSVLDTLLAPSGPEQSQTSPPACEAITSW CLFGPELPEDPRSVPATKGLLSPLMSRPESKAGDSSGTGAGQKVLPKAVSPPRQLLLPTSGSAHWPGAGV KPSQQPATVEVEEDGGLETEGSAGPLLKSKPRALEGMCSGGGVTANAPGAAPGGVTLVPKEDSRFSAPRV SLEQDAPVAPGRSPLATTVVDFIHVPILPLNHALLAARTRQLLEGDSYDGGAAAQVPFAPPRGSPSAPSP PVPCGDFPDCTYPPEGDPKEDGFPVYGEFQPPGLKIKEEEEGTEAASRSPRPYLLAGASAATFPDFPLPP RPPRAPPSRPGEAAVAAPSAAVSPVSSSGSALECILYKAEGAPPTQGSFAPLPCKPPAASSCLLPRDSLP AAPTSSAAPAIYPPLGLNGLPQLGYQAAVLKDSLPQVYPPYLNYLRPDSEASQSPQYGFDSLPQKICLIC GDEASGCHYGVLTCGSCKVFFKRAMEGQHNYLCAGRNDCIVDKIRRKNCPACRLRKCCQAGMVLGGRKFK KFNKVRVMRALDGVALPQSVAFPNESQTLGQRITFSPNQEIQLVPPLINLLMSIEPDVVYAGHDNTKPDT SSSLLTSLNQLGERQLLSVVKWSKSLPGFRNLHIDDQITLIQYSWMSLMVFGLGWRSYKHVSGQMLYFAP DLILNEQRMKELSFYSLCLTMWQIPQEFVKLQVTHEEFLCMKVLLLLNTIPLEGLRSQSQFEEMRSSYIR ELIKAIGLRQKGVVPSSQRFYQLTKLLDSLHDLVKQLHLYCLNTFIQSRALAVEFPEMMSEVIAAQLPKI LAGMVKPLLFHKK |
| Ensembl Gene | |
|---|---|
| UniGene |
Rn.10303 |
| PDB | |
| RefSeq |
NP_074038.1 |
| Pfam |
PF00104 PF00105 PF02161 |