androgen receptor

General Information (Source: NCBI Gene,UniProt)

Text mining Term androgen receptor
UniProt ID ANDR_RAT
Name Dihydrotestosterone receptor
Nuclear receptor subfamily 3 group C member 4
Androgen receptor
Gene Names Ar
Synonyms:Nr3c4
Taxonomy Rattus norvegicus

General annotation

Function Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins. Transcription activation is down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3 (By similarity).
Subcellular location Nucleus. Cytoplasm (By similarity). Note=Predominantly cytoplasmic in unliganded form but translocates to the nucleus upon ligand-binding. Can also translocate to the nucleus in unliganded form in the presence of GNB2L1 (By similarity).

Gene Ontology

GO:0032868 response to insulin stimulus BP
GO:0044212 transcription regulatory region DNA binding MF
GO:0045720 negative regulation of integrin biosynthetic process BP
GO:0043066 negative regulation of apoptotic process BP
GO:0034339 regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor BP
GO:0050681 androgen receptor binding MF
GO:0000790 nuclear chromatin CC
GO:0030424 axon CC
GO:0045944 positive regulation of transcription from RNA polymerase II promoter BP
GO:0003700 sequence-specific DNA binding transcription factor activity MF
GO:0003706 ligand-regulated transcription factor activity MF
GO:0004882 androgen receptor activity MF
GO:0005497 androgen binding MF
GO:0008284 positive regulation of cell proliferation BP
GO:0042327 positive regulation of phosphorylation BP
GO:0090003 regulation of establishment of protein localization in plasma membrane BP
GO:0008270 zinc ion binding MF
GO:0008013 beta-catenin binding MF
GO:0006351 transcription, DNA-dependent BP
GO:0051092 positive regulation of NF-kappaB transcription factor activity BP
GO:0005737 cytoplasm CC
GO:0030425 dendrite CC

Sequence

>gi|6978535|ref|NP_036634.1| androgen receptor [Rattus norvegicus]
MEVQLGLGRVYPRPPSKTYRGAFQNLFQSVREAIQNPGPRHPEAASIAPPGACLQQRQETSPRRRRRQQH
PEDGSPQAHIRGTTGYLALEEEQQPSQQQSASEGHPESGCLPEPGAATAPGKGLPQQPPAPPDQDDSAAP
STLSLLGPTFPGLSSCSADIKDILSEAGTMQLLQQQQQQQQQQQQQQQQQQQQQQEVISEGSSSVRAREA
TGAPSSSKDSYLGGNSTISDSAKELCKAVSVSMGLGVEALEHLSPGEQLRGDCMYASLLGGPPAVRPTPC
APLAECKGLSLDEGPGKGTEETAEYSSFKGGYAKGLEGESLGCSGSSEAGSSGTLEIPSSLSLYKSGAVD
EAAAYQNRDYYNFPLALSGPPHPPPPTHPHARIKLENPSDYGSAWAAAAAQCRYGDLASLHGGSVAGPST
GSPPATASSSWHTLFTAEEGQLYGPGGGGGSSSPSDAGPVAPYGYTRPPQGLASQEGDFSASEVWYPGGV
VNRVPYPSPSCVKSEMGPWMENYSGPYGDMRLDSTRDHVLPIDYYFPPQKTCLICGDEASGCHYGALTCG
SCKVFFKRAAEGKQKYLCASRNDCTIDKFRRKNCPSCRLRKCYEAGMTLGARKLKKLGNLKLQEEGENSS
AGSPTEDPSQKMTVSHIEGYECQPIFLNVLEAIEPGVVCAGHDNNQPDSFAALLSSLNELGERQLVHVVK
WAKALPGFRNLHVDDQMAVIQYSWMGLMVFAMGWRSFTNVNSRMLYFAPDLVFNEYRMHKSRMYSQCVRM
RHLSQEFGWLQITPQEFLCMKALLLFSIIPVDGLKNQKFFDELRMNYIKELDRIIACKRKNPTSCSRRFY
QLTKLLDSVQPIARELHQFTFDLLIKSHMVSVDFPEMMAEIISVQVPKILSGKVKPIYFHTQ

Options for BLAST

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Database Cross Reference

Ensembl Gene ENSRNOT00000009129
UniGene Rn.9813
PDB 3G0W
1I37
1I38
1R4I
2IHQ
2NW4
1XNN
RefSeq NP_036634.1
Pfam PF00105
PF02166
PF00104