| Text mining Term | dihydrofolate reductase |
|---|---|
| UniProt ID | DYR_ECOLI |
| Name |
Dihydrofolate reductase |
| Gene Names |
folA
Synonyms:tmrA |
| Taxonomy | Escherichia coli K-12 |
| Function |
Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. |
|---|---|
| Subcellular location |
| GO:0006545 | glycine biosynthetic process | BP |
| GO:0004146 | dihydrofolate reductase activity | MF |
| GO:0046677 | response to antibiotic | BP |
| GO:0009165 | nucleotide biosynthetic process | BP |
| GO:0042493 | response to drug | BP |
| GO:0031427 | response to methotrexate | BP |
| GO:0006730 | one-carbon metabolic process | BP |
| GO:0050661 | NADP binding | MF |
| GO:0009257 | 10-formyltetrahydrofolate biosynthetic process | BP |
>gi|16128042|ref|NP_414590.1| dihydrofolate reductase [Escherichia coli str. K-12 substr. MG1655] MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIILSSQPGTDD RVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGDTHFPDYEPDDWESVFSEF HDADAQNSHSYCFEILERR |
| Ensembl Gene | |
|---|---|
| UniGene | |
| PDB |
3K74 1DYJ 1DYI 6DFR 1RE7 3DAU 1RC4 1DYH 2INQ 1RF7 1RH3 1DDS 1RX9 1RX4 1DHJ 1RX6 1JOM 1RA3 1RX2 2ANQ 1RA2 1RX1 1DRB 1DHI 1RX8 1RG7 1RA8 1RA1 1JOL 1RX5 1RD7 3DRC 1DRH 1DRE 1RB2 1RX7 1RX3 3KFY 7DFR 4DFR 2D0K 1RB3 1DRA 1TDR 2ANO 2DRC 3OCH 1DDR 1RA9 3QL3 5DFR |
| RefSeq |
NP_414590.1 |
| Pfam |
PF00186 |