dihydrofolate reductase

General Information (Source: NCBI Gene,UniProt)

Text mining Term	dihydrofolate reductase
UniProt ID	DYR_ECOLI
Name	Dihydrofolate reductase
Gene Names	folA Synonyms:tmrA
Taxonomy	Escherichia coli K-12

General annotation

Function	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.
Subcellular location

Gene Ontology

GO:0009257	10-formyltetrahydrofolate biosynthetic process	BP
GO:0009165	nucleotide biosynthetic process	BP
GO:0031427	response to methotrexate	BP
GO:0006730	one-carbon metabolic process	BP
GO:0004146	dihydrofolate reductase activity	MF
GO:0006545	glycine biosynthetic process	BP
GO:0046677	response to antibiotic	BP
GO:0042493	response to drug	BP
GO:0050661	NADP binding	MF

Sequence

>gi|16128042|ref|NP_414590.1| dihydrofolate reductase [Escherichia coli str. K-12 substr. MG1655]
MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIILSSQPGTDD
RVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGDTHFPDYEPDDWESVFSEF
HDADAQNSHSYCFEILERR

Database Cross Reference

Ensembl Gene
UniGene
PDB	1JOL 2DRC 6DFR 1DRE 2ANO 2INQ 1RX3 1RX1 1RE7 1DYH 1RX6 1RB3 1RD7 1DDR 3OCH 1DYJ 1RC4 3DRC 4DFR 1RA2 1TDR 1JOM 1DDS 1DRA 3K74 3QL3 1RA9 1RX4 1RB2 1DRB 3DAU 1DYI 1RX9 1RA1 2D0K 1RX5 1DHJ 1DRH 1RA3 1RX2 3KFY 1RG7 1RA8 1RX8 1RF7 2ANQ 1DHI 1RH3 5DFR 7DFR 1RX7
RefSeq	NP_414590.1
Pfam	PF00186

PTID

dihydrofolate reductase

General Information (Source: NCBI Gene,UniProt)

General annotation

Gene Ontology

Sequence

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Database Cross Reference