dihydrofolate reductase

General Information (Source: NCBI Gene,UniProt)

Text mining Term	dihydrofolate reductase
UniProt ID	DYR_ECOLI
Name	Dihydrofolate reductase
Gene Names	folA Synonyms:tmrA
Taxonomy	Escherichia coli K-12

General annotation

Function	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.
Subcellular location

Gene Ontology

GO:0004146	dihydrofolate reductase activity	MF
GO:0031427	response to methotrexate	BP
GO:0050661	NADP binding	MF
GO:0046677	response to antibiotic	BP
GO:0006545	glycine biosynthetic process	BP
GO:0009165	nucleotide biosynthetic process	BP
GO:0006730	one-carbon metabolic process	BP
GO:0042493	response to drug	BP
GO:0009257	10-formyltetrahydrofolate biosynthetic process	BP

Sequence

>gi|16128042|ref|NP_414590.1| dihydrofolate reductase [Escherichia coli str. K-12 substr. MG1655]
MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIILSSQPGTDD
RVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGDTHFPDYEPDDWESVFSEF
HDADAQNSHSYCFEILERR

Database Cross Reference

Ensembl Gene
UniGene
PDB	1RA1 1RC4 1RX3 1RB3 1DRA 2DRC 1RA8 2ANQ 1RX6 1RA3 1RF7 1DDR 1DYI 3K74 1RX4 3OCH 1TDR 1DYH 1DYJ 1DRH 1DDS 7DFR 2D0K 2ANO 1RE7 1JOM 1RX9 6DFR 1RD7 1RG7 1RX2 5DFR 1RA9 1RX8 1DHI 1RB2 1DHJ 1RX5 1DRB 1RX7 1JOL 4DFR 3KFY 3DAU 3DRC 1RX1 1RH3 1RA2 1DRE 2INQ 3QL3
RefSeq	NP_414590.1
Pfam	PF00186

PTID

dihydrofolate reductase

General Information (Source: NCBI Gene,UniProt)

General annotation

Gene Ontology

Sequence

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Database Cross Reference