dihydrofolate reductase

General Information (Source: NCBI Gene,UniProt)

Text mining Term	dihydrofolate reductase
UniProt ID	DYR_ECOLI
Name	Dihydrofolate reductase
Gene Names	folA Synonyms:tmrA
Taxonomy	Escherichia coli K-12

General annotation

Function	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.
Subcellular location

Gene Ontology

GO:0006730	one-carbon metabolic process	BP
GO:0009257	10-formyltetrahydrofolate biosynthetic process	BP
GO:0009165	nucleotide biosynthetic process	BP
GO:0006545	glycine biosynthetic process	BP
GO:0042493	response to drug	BP
GO:0031427	response to methotrexate	BP
GO:0004146	dihydrofolate reductase activity	MF
GO:0046677	response to antibiotic	BP
GO:0050661	NADP binding	MF

Sequence

>gi|16128042|ref|NP_414590.1| dihydrofolate reductase [Escherichia coli str. K-12 substr. MG1655]
MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIILSSQPGTDD
RVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGDTHFPDYEPDDWESVFSEF
HDADAQNSHSYCFEILERR

Database Cross Reference

Ensembl Gene
UniGene
PDB	1RG7 5DFR 2DRC 1DHI 3DAU 4DFR 1DRH 1TDR 2INQ 1JOL 1RD7 3KFY 1RX3 1RX9 7DFR 1RB3 1RA1 1DRA 3DRC 1RF7 1RA9 1DYJ 1RH3 1DHJ 1RA2 1RX2 1RA8 1JOM 1RX4 1RX6 1DDS 2ANO 1RX1 1DYH 6DFR 1RX8 1DDR 1RX5 1RC4 1RB2 3QL3 1DYI 1RX7 1RE7 1RA3 2ANQ 3K74 2D0K 1DRB 3OCH 1DRE
RefSeq	NP_414590.1
Pfam	PF00186

PTID

dihydrofolate reductase

General Information (Source: NCBI Gene,UniProt)

General annotation

Gene Ontology

Sequence

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Database Cross Reference