dihydrofolate reductase

General Information (Source: NCBI Gene,UniProt)

Text mining Term	dihydrofolate reductase
UniProt ID	DYR_ECOLI
Name	Dihydrofolate reductase
Gene Names	folA Synonyms:tmrA
Taxonomy	Escherichia coli K-12

General annotation

Function	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.
Subcellular location

Gene Ontology

GO:0009165	nucleotide biosynthetic process	BP
GO:0031427	response to methotrexate	BP
GO:0006730	one-carbon metabolic process	BP
GO:0050661	NADP binding	MF
GO:0042493	response to drug	BP
GO:0004146	dihydrofolate reductase activity	MF
GO:0006545	glycine biosynthetic process	BP
GO:0009257	10-formyltetrahydrofolate biosynthetic process	BP
GO:0046677	response to antibiotic	BP

Sequence

>gi|16128042|ref|NP_414590.1| dihydrofolate reductase [Escherichia coli str. K-12 substr. MG1655]
MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIILSSQPGTDD
RVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGDTHFPDYEPDDWESVFSEF
HDADAQNSHSYCFEILERR

Database Cross Reference

Ensembl Gene
UniGene
PDB	1RX5 1RF7 2INQ 3OCH 1DHI 1DRH 6DFR 5DFR 1RA9 1TDR 1DDR 1RA3 1RD7 2ANQ 1DRE 1DYJ 1RA8 1RX9 1DDS 1RX8 1RX2 1RB2 3K74 3KFY 1RC4 1RE7 1RB3 1RX1 1RX7 1RH3 1DRB 1JOM 7DFR 1RX6 3DRC 1RX4 3QL3 2DRC 2D0K 3DAU 1JOL 1RG7 4DFR 1RA2 1DYI 1RX3 1RA1 2ANO 1DHJ 1DRA 1DYH
RefSeq	NP_414590.1
Pfam	PF00186

PTID

dihydrofolate reductase

General Information (Source: NCBI Gene,UniProt)

General annotation

Gene Ontology

Sequence

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Database Cross Reference